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Direct modulation of firing activity by dopamine D2 like receptors in the globus pallidus of both normal and parkinsonian rats

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2016.0077

Key Word:: 苍白球;多巴胺D2样受体;帕金森病;globus pallidus;dopamine D2 like receptors;Parkinson's disease

Abstract：苍白球是基底神经节间接环路的重要核团,在机体正常及病理状态下调节运动功能.前期研究工作显示苍白球接受来自黑质纹状体轴突侧支的多巴胺能纤维支配.苍白球表达多巴胺D1和D2样受体.本研究旨在采用多管微电极细胞外电生理记录技术,探讨多巴胺D2样受体对正常及帕金森病模型大鼠苍白球神经元自发放电的直接调控效应.结果显示,在正常大鼠上,微压力给予多巴胺D2样受体激动剂quinpirole对苍白球神经元自发放电发挥不同的电生理效应.在所记录的61个苍白球神经元,quinpirole可使24个神经元的放电频率增加(62.7±l 1.2)％,而使另外1 6个神经元放电频率降低(37.5±2.9)％,联合给予D2样受体阻断剂sulpride可阻断quinpirole对苍白球神经元自发放电的调控效应.在6-羟基多巴胺(6-hydroxydopamine,6-OHDA)帕金森病模型大鼠损毁侧所记录的47个苍白球神经元中,quinpirole可使其中25个神经元的放电频率增加(64.2±10.1)％,而使另外11个神经元放电频率降低(51.9±6.2)％.以上结果提示,多巴胺D2样受体双向调节苍白球神经元的自发放电活动;在帕金森病状态下,多巴胺D2样受体仍具有双向调节苍白球神经元兴奋性的效应.

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