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An overview on autophagy in neural stem cells

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2016.0065

Key Word:: 自噬;神经干细胞;凋亡;增殖;分化;autophagy;neural stem cells;apoptosis;proliferation;differentiation

Abstract：神经干细胞(neural stem cells,NSCs)移植是神经退行性疾病新的治疗途径,但移植细胞在动物模型的存活率和分化率需进一步提高.因此了解调节NSCs存活和死亡的机制,对于发展以干细胞移植为基础的治疗方法至关重要.自噬是维持细胞稳态的重要途径,可通过影响NSCs的存活和增殖等生物学行为进而改变NSCs的命运.本文就自噬和NSCs关系做一综述,从存活、凋亡、增殖和分化及其相关机制等方面展示自噬对NSCs命运的影响.

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