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Photodynamic modulation of cellular functions

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: 10.13294/j.aps.2016.0053

Key Word:: 光敏作用;光敏化合物;可见光;光生物效应;光化学效应;photosensitization;photosensitiser;visible light;photobiology;photochemistry

Abstract：光动力作用所产生的单线态氧分子因其有限的寿命(1μs)和有效反应距离(＜ 10 nm),可亚细胞特异性调控细胞的不同生理活动.如质膜定位的光动力作用可导致胆囊收缩素(cholecystokinin,CCK)1型受体的永久性激活,及其它G蛋白耦联受体的增敏或脱敏.近年来涌现出来的基因编码的蛋白质光敏剂,使得光动力作用的亚细胞定位变得更加精细可控,因而可实现亚细胞部位及功能蛋白的靶向光动力调控.蛋白质光敏剂毒杀红(KillerRed)、迷你单(miniSOG)、单蛋敏(singlet oxygen protein photosensitiser,SOPP)等的亚细胞定位表达,可光动力调控细胞局部生理过程,通过对特定蛋白的光氧化活性改变,阐明该蛋白在细胞生理过程中的作用.选择性光照技术,可实现同步多点局部光照.多点局部光动力作用调控,可阐明细胞局部对整体细胞,及个体细胞对细胞团块的影响.蛋白质光敏剂的光动力作用,正逐渐成为细胞生理学研究的重要纳米调控工具.

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