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Refractive development and form-deprivation induced myopic refractive error in CBA/CaJ mice

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 2

DOI:: 10.13294/j.aps.2016.0018

Key Word:: 近视;褪黑素;形觉剥夺;屈光力;CBA小鼠;myopia;melatonin;form-deprivation;refractive error;CBA mouse

Abstract：小鼠因易于进行遗传学操作,成为近视机制研究中最为常用的哺乳类模式动物之一.然而,绝大多数品系的实验用小鼠不具备褪黑素合成能力,而这一神经激素在人类近视形成过程中可能起重要的作用.本工作研究了一种体内能合成褪黑素的小鼠品系——CBA/CaJ品系的屈光发育特征,并阐明了形觉剥夺是否影响屈光发育及其机制.使用红外偏心验光仪的连续观察显示,CBA/CaJ小鼠眼球屈光力可被稳定测量,且呈现明显的发育学变化:屈光力数值随日龄逐渐增大,直至出生后9周左右才渐趋稳定.其屈光力绝对值高于目前常用的C57BL/6小鼠同龄时的数值,但屈光力开始稳定的时间点则较为接近.给3周龄CBA/CaJ小鼠佩戴半透明眼罩,施加形觉剥夺5周后,剥夺眼屈光力相对对侧眼出现显著的近视性偏移,表明该品系小鼠可用于形觉剥夺性近视建模.

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