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Response characteristics of neurons to tone in dorsal nucleus of the lateral lemniscus of the mouse

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 1

DOI:: 10.13294/j.aps.2016.0006

Key Word:: 外侧丘系背核;发放模式;频率调谐;强度调谐;小鼠;dorsal nuclei of lateral lemniscus;firing pattern;frequency tuning;intensity tuning;mouse

Abstract：外侧丘系背核(dorsal nuclei of lateral lemniscus,DNLL)是听觉信息上传通路中的神经核团,是下丘抑制性输入的重要来源.目前对DNLL的研究远不如对听觉低位脑干和中脑下丘那么广泛而深入,对于小鼠这种常用听觉模式动物的DNLL的研究尚未见报道.本实验在自由声场条件下,采用单单位细胞外记录的方法,研究了昆明小鼠(Mus musculus,Km) DNLL神经元对纯音的声反应特性.实验结果显示,小鼠DNLL神经元对纯音刺激的发放模式分为瞬时型(36％)与长时型(64％)两类,两类发放模式对应的特征频率和阈值存在显著性差异.DNLL神经元的频率调谐曲线(frequency tuning curves,FTCs)均为开放的“V”型,瞬时型与长时型神经元的FTC无显著差异,但长时型神经元中持续型神经元的FTC明显较起始-持续型和暂停型神经元更为锐化.与猫等动物不同,小鼠DNLL神经元的特征频率与深度之间无线性相关(P＞0.05),未见背腹轴音频拓扑组构.DNLL神经元的放电率-强度函数(rate-intensity function,RIF)分为单调型(60％)、饱和型(31％)和非单调型(8％).三种RIF均包含瞬时型与长时型发放模式,瞬时型神经元对应的动态范围显著小于长时型(P＜0.01),这可能与瞬时型神经元接受较多的抑制性输入有关.小鼠DNLL神经元存在多样的发放模式和声强编码方式,源于其接受多个听觉核团的投射,其在听觉信息的处理过程中发挥不同的作用.

Reference

[1]王丹,皮建辉,唐佳,等.弱噪声对下丘神经元声强敏感性的动态调制[J].2005,(1).
[2]Ohmori H,Fukui I,Sato T.Interaural phase difference modulates the neural activity in the nucleus angularis and improves the processing of level difference cue in the lateral lemniscal nucleus in the chicken.[J].2010,66(2).
[3]V M, Bajo,A E, Villa,F, de Ribaupierre,etc.Discharge properties of single neurons in the dorsal nucleus of the lateral lemniscus of the rat.[J].1998,47(6).
[4]Zi-Ying Fu,Hui-Xian Mei,LIANG Cheng,etc.Local neuronal circuits that may shape the discharge patterns of inferior collicular neurons[J].2013,(5).
[5]Yang, L.,Pollak, G. D..Features of ipsilaterally evoked inhibition in the dorsal nucleus of the lateral lemniscus[J].1998,122(1).
[6]S A, Kidd,J B, Kelly.Contribution of the dorsal nucleus of the lateral lemniscus to binaural responses in the inferior colliculus of the rat: interaural time delays.[J].1996,16.
[7]M A, Merchán,E, Salda?a,I, Plaza.Dorsal nucleus of the lateral lemniscus in the rat: concentric organization and tonotopic projection to the inferior colliculus.[J].1994,342(2).
[8]Klug A,Bauer EE,Pollak GD.Spectral determination of responses to species-specific calls in the dorsal nucleus of the lateral lemniscus.[J].2002,88(4).
[9]L M, Aitkin,D J, Anderson,J F, Brugge.Tonotopic organization and discharge characteristics of single neurons in nuclei of the lateral lemniscus of the cat.[J].1970,33.
[10]Fathke RL,Gabriele ML.Patterning of multiple layered projections to the auditory midbrain prior to experience.[J].2009,249(1).
[11]Shen JX,Tang J,Xiao ZJ.Delayed inhibition creates amplitude tuning of mouse inferior collicular neurons.[J].2008,19(15).
[12]Markovitz, N. S.,Pollak, G. D..The dorsal nucleus of the lateral lemniscus in the mustache bat: Monaural properties[J].1993,71(1).
[13]E, Covey.Response properties of single units in the dorsal nucleus of the lateral lemniscus and paralemniscal zone of an echolocating bat.[J].1993,69.
[14]Meyer, K.,Rouiller, E. M.,Loquet, G..Direct comparison between properties of adaptation of the auditory nerve and the ventral cochlear nucleus in response to repetitive clicks[J].2007,228(1).
[15]Batra R,Kuwada S,Fitzpatrick DC,etc.Sensitivity to interaural time differences in the dorsal nucleus of the lateral lemniscus of the unanesthetized rabbit: comparison with other structures.[J].2006,95(3).
[16]Jia, Tang,Fei-Jian, Wu,Dan, Wang,etc.The amplitude sensitivity of mouse inferior collicular neurons in the presence of weak noise.[J].2007,50(4).
[17]Kevin A, Davis,Oleg, Lomakin,Michael J, Pesavento.Response properties of single units in the dorsal nucleus of the lateral lemniscus of decerebrate cats.[J].2007,98.
[18]齐巧珍,佀文娟,罗峰,等.小鼠初级听皮质神经元的强度调谐特性与机制分析[J].2013,(4).
[19]Tao HW,Li P,Wu GK,etc.Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuning.[J].2006,52(4).
[20]Yavuzoglu A,Wenstrup JJ,Schofield BR.Substrates of auditory frequency integration in a nucleus of the lateral lemniscus.[J].2010,169(2).
[21]Ito M,van Adel B,Kelly JB.Sound localization after transection of the commissure of Probst in the albino rat.[J].1996,76(5).
[22]Vanrullen R,Guyonneau R,Thorpe SJ.Spike times make sense.[J].2005,28(1).
[23]Liu Q,Pollak GD,Yang L.Afferent connections to the dorsal nucleus of the lateral lemniscus of the mustache bat: evidence for two functional subdivisions.[J].1996,373(4).
[24]E, Covey,M, Vater,J H, Casseday.Binaural properties of single units in the superior olivary complex of the mustached bat.[J].1991,66.
[25]Heil P.First-spike latency of auditory neurons revisited.[J].2004,14(4).
[26]Brunso-Bechtold JK,Henkel CK,Franklin SR.Bilateral cochlear ablation in postnatal rat disrupts development of banded pattern of projections from the dorsal nucleus of the lateral lemniscus to the inferior colliculus.[J].2008,154(1).
[27]Pollak, G.D..Discriminating among complex signals: The roles of inhibition for creating response selectivities[J].2011,197(5).
[28]L, Yang,G D, Pollak,C, Resler.GABAergic circuits sharpen tuning curves and modify response properties in the mustache bat inferior colliculus.[J].1992,68.
[29]Kelly, J. B.,Liscum, A.,Van Adel, B.,etc.Projections from the superior olive and lateral lemniscus to tonotopic regions of the rat's inferior colliculus[J].1998,116(1).
[30]Guyonneau R,VanRullen R,Thorpe SJ.Neurons tune to the earliest spikes through STDP[J].2005,17(4).
[31]Kelly, J. B.,Buckthought, A. D.,Kidd, S. A..Monaural and binaural response properties of single neurons in the rat's dorsal nucleus of the lateral lemniscus[J].1998,122(1).
[32]L, Yang,G D, Pollak.GABA and glycine have different effects on monaural response properties in the dorsal nucleus of the lateral lemniscus of the mustache bat.[J].1994,71.
[33]Pollak, G. D..The dominant role of inhibition in creating response selectivities for communication calls in the brainstem auditory system[J].2013,305(1).
[34]Wu SH.Synaptic excitation in the dorsal nucleus of the lateral lemniscus.[J].1999,57(3).
[35]Manuel S, Malmierca.The structure and physiology of the rat auditory system: an overview.[J].2003,56.
[36]J B, Kelly,L, Li,B, van Adel.Sound localization after kainic acid lesions of the dorsal nucleus of the lateral lemniscus in the albino rat.[J].1996,110.
[37]K K, Glendenning,J K, Brunso-Bechtold,G C, Thompson,etc.Ascending auditory afferents to the nuclei of the lateral lemniscus.[J].1981,197(4).
[38]Pollak GD,Klug A,Grothe B,etc.Inhibiting the inhibition: a neuronal network for sound localization in reverberant environments.[J].2007,27(7).
[39]Jen PH,Zhang J.The role of GABAergic inhibition on direction-dependent sharpening of frequency tuning in bat inferior collicular neurons.[J].2000,862(1).
[40]X.W Fu,B.L Brezden,J.B Kelly,etc.Synaptic excitation in the dorsal nucleus of the lateral lemniscus: whole-cell patch-clamp recordings from rat brain slice[J].1997,78(3).
[41]Yang L,Pollak GD.Differential response properties to amplitude modulated signals in the dorsal nucleus of the lateral lemniscus of the mustache bat and the roles of GABAergic inhibition.[J].1997,77(1).
[42]Seidl AH,Siveke I,Grothe B,etc.Binaural response properties of low-frequency neurons in the gerbil dorsal nucleus of the lateral lemniscus.[J].2006,96(3).
[43]Brezden BL,Fu XW,Wu SH,etc.Potassium currents and membrane excitability of neurons in the rat's dorsal nucleus of the lateral lemniscus.[J].1996,76(2).
[44]Winer JA,Pollak GD,Larue DT.GABA and glycine in the central auditory system of the mustache bat: structural substrates for inhibitory neuronal organization.[J].1995,355(3).
[45]B, Grothe,M, Vater,J H, Casseday,etc.Monaural interaction of excitation and inhibition in the medial superior olive of the mustached bat: an adaptation for biosonar.[J].1992,89.
[46]Kutscher A,Covey E.Functional role of GABAergic and glycinergic inhibition in the intermediate nucleus of the lateral lemniscus of the big brown bat.[J].2009,101(6).