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The influence of interfered circadian rhythm on pregnancy and neonatal rats

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 5

DOI:: 10.13294/j.aps.2015.0064

Key Word:: 日节律紊乱;持续光照;褪黑素;妊娠大鼠;子代;interfered circadian rhythm;continuous light;melatonin;pregnant rats;neonatal rats

Abstract：本研究利用持续光照大鼠模型,观察日节律紊乱对大鼠妊娠及其子代早期的生长发育的影响,并初步探讨其与褪黑素及孕酮变化的关系.妊娠期给予24 h持续光照,观察日节律紊乱对大鼠分娩的影响.大鼠受孕后,在不同妊娠阶段采集血清,检测褪黑素和孕酮水平.在妊娠15日龄,随机选取一半孕鼠,剖腹观察胚胎吸收率.剩余母鼠继续饲养,观察分娩情况及产后仔鼠生长发育情况.结果显示:(1)持续光照条件下的日节律紊乱,可以导致大鼠不良妊娠结局,胚胎吸收率上升,活产仔鼠数量下降;(2)持续光照条件下的日节律紊乱,可以抑制褪黑素分泌,降低孕酮水平;(3)持续光照条件下的日节律紊乱,可以干扰大鼠的分娩节律,导致分娩时程延长,但对妊娠天数没有产生影响;(4)孕期大鼠暴露于持续光照条件下的日节律紊乱状态,可以影响仔鼠的宫内发育及子代早期生长发育.以上结果表明,持续光照导致的日节律紊乱,对于妊娠大鼠及新生大鼠,均会产生不良影响.本研究为临床指导孕期女性生物节律调节以及褪黑素的应用,提供理论依据.

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