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Alteration of neural oscillations in hippocampal CA3 area in the fast avoidance response rat before and after electric shock avoidance training
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- Author:
- No author available
- Journal Title:
- Acta Physiologica Sinica
- Issue:
- 5
- DOI:
- 10.13294/j.aps.2015.0060
- Key Word:
- 电击回避训练;海马CA3区;局部场电位;神经振荡;electric shock avoidance training;hippocampus CA3 region;local field potential;neural oscillations
Abstract： 本研究旨在探讨与动物空间辨别学习能力相关的神经振荡电活动及其改变.运用Y型迷宫电击回避训练方法,筛选出与空间认知能力相关的快回避反应组和普通回避反应组大鼠,无线遥测两组动物在电击回避实验前、后海马CA3区实时局部场电位(local field potential,LFP),分析与空间辨别和学习能力相关的神经振荡成分变化.结果显示,与普通回避反应组大鼠比较,电击回避训练前快回避反应组大鼠左侧海马CA3区LFP成分无显著差异,但电击回避训练后,右侧海马CA3区0～10 Hz和30～40 Hz电节律百分比显著增加(P＜ 0.01或P＜0.05);快速傅里叶变换显示,0～10 Hz频段百分比增加主要发生在θ波(3～7 Hz)频段,而30～40 Hz频段改变相当于γ1频段.进一步将两组大鼠训练前后的右侧CA3区神经振荡进行自身比较,结果显示训练后快回避反应组大鼠仅出现β波、β2(20～30 Hz)和γ1节律百分比增加,θ波节律百分比在训练前后无明显变化,而普通回避反应组大鼠训练前后比较显示,训练后右侧CA3区θ波节律百分比和大幅波(强度:+2.5 ～-2.5 db)显著减少(P＜0.01).本研究结果显示,快回避反应组大鼠电击回避训练后,右侧海马CA3区β2和γ1节律百分比增加,θ波节律百分比保持较高水平,这些改变可能与其较强的空间认知能力有关.
- [1]杨帮华,颜国正,鄢波.基于离散小波变换提取脑机接口中脑电特征[J].2006,(5).
- [2]Shirvalkar, PR,Shapiro, ML,Rapp, PR.Bidirectional changes to hippocampal theta-gamma comodulation predict memory for recent spatial episodes[J].2010,107(15).
- [3]Y P, Tang,E, Shimizu,G R, Dube,etc.Genetic enhancement of learning and memory in mice.[J].1999,401(6748).
- [4]Stephanie, Jacobs,Zhenzhong, Cui,Ruiben, Feng,etc.Molecular and genetic determinants of the NMDA receptor for superior learning and memory functions.[J].2014,9(10).
- [5]Wikenheiser, Andrew M.,Redish, A. David.Hippocampal theta sequences reflect current goals[J].2015,18(2).
- [6]P T, Huerta,J E, Lisman.Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state.[J].1993,364.
- [7]Zhenzhong, Cui,Ruiben, Feng,Stephanie, Jacobs,etc.Increased NR2A: NR2B ratio compresses long-term depression range and constrains long-term memory.[J].2013,3.
- [8]Carsten Finke,Thomas Nicolas Lehmann,Christoph J. Ploner,etc.Lesions Affecting the Right Hippocampal Formation Differentially Impair Short-Term Memory of Spatial and Nonspatial Associations[J].2011,21(3).
- [9]Hosoya,A.,Ahmed,H.,Shinohara,Y.,etc.Right-hemispheric dominance of spatial memory in split-brain mice[J].2012,22(2).
- [10]张涛.与突触可塑性相关的神经振荡和信息流研究[J].2011,(5).
- [11]Mikkonen JE,Penttonen M,Huttunen J.Contribution of a single CA3 neuron to network synchrony.[J].2006,31(3).
- [12]Xu, Xiaxia,An, Lei,Mi, Xichao,etc.Impairment of Cognitive Function and Synaptic Plasticity Associated with Alteration of Information Flow in Theta and Gamma Oscillations in Melamine-Treated Rats.[J].2013,8(10).
- [13]Kopell, NJ,Eichenbaum, H,Komorowski, RW,etc.Theta-gamma coupling increases during the learning of item-context associations[J].2009,106(49).