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The role of extracellular ATP in the male reproductive tract

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Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 4

DOI:: 10.3321/j.issn:0371-0874.2007.04.009

Key Word:: ATP;附睾;输精管;上皮分泌;平滑肌收缩;ATP;epididymis;vas deferens;epithelial secretion;smooth muscle contraction

Abstract： In addition to its well established role as a neurotransmitter, extracellular ATP has been considered as a paracrine/autocrine factor, either released from sperm or epithelial cells, in the male reproductive tract and shown to play a versatile role in modulating various reproductive functions. This review summarizes the signal pathways through which ATP induces anion secretion by the epithelia of the epididymis, as well as its epithelium-dependent modulation of smooth muscle contraction of the vas deferens. Finally,the overall role of ATP in coordinating various reproductive events in the male genital tract is discussed.

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