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Effect of arginine vasopressin on membrane potential of dorsal root ganglion neurons in rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0371-0874.2004.01.019
- Key Word:
- 背根神经节;细胞内记录;血管升压素;升压素受体
Abstract： 为研究血管升压素(arginine vasopressin,AVP)对大鼠背根神经节(dorsal root ganglion,DRG)神经元的作用及其机制,用细胞内微电极记录技术记录离体灌流DRG神经元的膜电位.结果如下:(1)在受检的120个细胞中,大多数(81.67%)在滴加AVP后产生明显的超极化反应.(2)滴加AVP(10μmol/L)后膜电导增加约19.34%(P＜0.05).(3)灌流平衡液中的NaCl以氯化胆碱(CH-C1)置代和用Cd2+阻断Ca2+通道后,AVP引起超极化反应的幅值均无明显变化(P＞0.05),而加入K+通道阻断剂四乙铵(TEA)后,AVP引起的超极化反应幅值明显减小(P＜0.05).(4)AVP引起的超极化反应可被AVP V1受体拮抗剂阻断.结果提示,AVP可使DRG大多数神经元膜产生超极化,DRG神经元膜上存在AVP V1受体,且AVP引起的超极化反应是通过神经元膜上AVP V1受体介导的K+外流所致,AVP 可能参与了初级感觉信息传入的调制.
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