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Limb ischemic preconditioning reduces infarct size following myocardial ischemia-reperfusion in rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0371-0874.2004.01.008
- Key Word:
- 缺血-再灌注;肢体预缺血;腺苷;心肌梗塞范围
Abstract： 在氨基甲酸乙酯麻醉大鼠上观察肢体预缺血(limbischemic preconditioning,LIP)对缺血-再灌注(ischemiareperfusion,IR)心肌的影响,旨在探讨LIP对IR心肌有无保护效应,并明确腺苷和神经通路是否参与此效应.所得结果如下:(1)在心脏缺血30 min和再灌注120 min过程中,梗塞心肌占缺血心肌的51.48±0.82%.(2)LIP时心肌梗塞范围为35.14±0.88%,较单纯心肌缺血-再灌注时显著减小(P＜0.01),表明LIP对心肌有保护作用.(3)事先切断股神经可取消LIP的保护效应.(4)股动脉内局部给予腺苷(10nmol/kg),可模拟LIP对心肌的保护作用;心肌梗塞范围是37.28±1.68%,而股静脉内注射同等剂量腺苷则无保护作用.(5)股动脉内预先应用腺苷A1受体拮抗剂8-环戊-1,3-二丙基嘌呤(DPCPX)(32 mo1/kg)可部分阻断LIP诱发的心肌保护效应.以上结果表明,肢体短暂预缺血可减小心肌缺血-再灌注后的梗塞范围,而局部释放的腺苷和由此所激活的相关的神经通路在LIP的心肌保护中起重要作用.
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