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Electrical activities of bursting-firing neurons in epileptic network reestablishment of rat hippocampus

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Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
6
DOI:
10.3321/j.issn:0371-0874.2003.06.008
Key Word:
癫痫网络;爆发式放电神经元;动作电位间期;强直电刺激;海马

Abstract´╝Ü 本文探讨双侧海马(hippocampus,HPC)神经网络中爆发式放电神经元(bursting-firing neurons,BFN)的活动规律及其与海马癫痫网络重建的关系.实验用雄性SD大鼠140只(150~250 g),急性强直电刺激(60 Hz,2 s,0.4~0.6 mA)右后背HPC CAl区(acute tetanization of the posterior dorsal hippocampus,ATPDH),同步记录同侧或对侧前背HPC单位放电和深部电图;强直电刺激右前背HPC(acute tetanization of the anterior dorsal hippocampus,AT-ADH),同步记录双侧前背HPC单位放电.实验共记录了13.8%(19/138)双侧前背HPC的BFN,其中13个为刺激诱发性BFN,6个为自发性BFN.强直电刺激引起的诱发反应包括:(1)ATPDH明显调制同侧前背HPC的BFN,产生规则的节律性爆发式放电,刺激后串内动作电位间期(bursting interspike interval,BISI)减小(P<0.001);(2)AT-PDH引起对侧前背HPC的BFN出现抑制后轻度调制效应,刺激后动作电位间期(interspike interval,ISI)增大(P<0.001);(3)ATADH后易化对侧前背HPC的自发性BFN节律,增加ISI(P<0.001)和IBI(P=0.01);(4)ATPDH诱导双侧前背HPC的BFN产生规则的节律性爆发式放电,伴有同步或非同步性网络癫痫的形成.上述实验结果提示,ATPDH沿同侧HPC长轴,跨大脑半球诱发前背HPC单个BFN的形成,其节律性爆发式放电与HPC癫痫网络的重建可能有关.

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