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Effect of removal of the adventitia on vascular remodeling and vasoconstriction in rabbits
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.2003.03.010
- Key Word:
- 外膜去除;内膜增生;血管反应性
Abstract： 本文研究血管外膜在血管重塑及功能调控中的作用.实验采用在体去除兔颈动脉外膜的方法, 于术后即刻、1周及2周取出动脉作组织学、免疫组织化学染色及血管反应性测定.结果显示: (1)去除颈动脉局部外膜对内皮及中层平滑肌无明显损伤; (2)去除外膜后血管平滑肌细胞增殖, 并有新生内膜形成; (3)与对照侧比较, 去外膜侧血管对去甲肾上腺素的收缩反应在术后即刻及1周时减弱(P<0.05).上述研究结果提示: 去除动脉外膜可导致血管内膜增殖及血管平滑肌收缩功能的改变, 表明外膜可能参与血管重塑及对血管功能的调控.
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