Thermal hyperalgesic effects induced by intracerebroventricular injection of interleukin-1β in rats
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.2002.04.010
- Key Word:
- 白介素-1β;热痛敏作用;脑;interleukin-1β;thermal hyperalgesia;brain
Abstract： The present study was to investigate the effects of intracerebroventricular (i.c.v.) injection of interleukin-1β (IL-1β) on thermal nociception in SD rats. The rats were divided into control and drug-administration groups. The animals of control group were given vehicle solution via i.c.v. injection. The animals of drug-administered groups were given IL-1β at different doses (5, 50 and 500 pg/kg b.w.) via i.c.v. injection. IL-1 receptor antagonist (IL-1ra, 50 ng/kg) was injected 20 min before injection of IL-1β or vehicle solution. The nociceptive threshold, which was represented as paw withdrawal latency (PWL), to a noxious thermal stimulation was measured using an analgesiameter. I.c.v. injection of IL-1β dose-dependently shortened the PWL. At the dose of 500 pg/kg, the shortening of the PWL occurred at 20 min, reaching a peak within 40 min, lasted 100 min after injection, then gradually returned to the baseline level. Pretreatment with IL-1ra completely blocked the effects of IL-1β-induced shortening in PWL. The results obtained suggest that IL-1β may induce hyperalgesia in rats through binding to IL-1 receptors in the brain.
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