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Changes in glycine content in mouse brain during hypoxic preconditioning
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0371-0874.2001.06.011
- Key Word:
- 甘氨酸;缺氧耐受性;缺氧预适应
Abstract： Glycine content of the whole brain and subregions was measured by high pressure liquid chromatography (HPLC) in mice during their repetitive exposures to hypoxia. The contents of glycine in whole brain, diencephalon, and hippocampus and brain stem was significantly increased as the animals′ tolerance to hypoxia was increased. The results suggest that glycine, as an inhibitory neurotransmitter in the brain, may positively contribute to the development of hypoxic preconditioning.
- [1]C E, Murry,R B, Jennings,K A, Reimer.Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.[J].1986,74(5).
- [2]D W, Choi.Glutamate receptors and the induction of excitotoxic neuronal death.[J].1994,100.
- [3]J W, Johnson,P, Ascher.Glycine potentiates the NMDA response in cultured mouse brain neurons.[J].1900,325(6104).
- [4]J M, Marshall,J D, Metcalfe.Analysis of the cardiovascular changes induced in the rat by graded levels of systemic hypoxia.[J].1988,407.
- [5]R W, Ransom,N L, Stec.Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines.[J].1988,51(3).
- [6]Choi DW,Grabb MC.Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors.[J].1999,19(5).
- [7]Yong Liu,Hiroyuki Kato,Naoki Nakata,etc.Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia[J].1992,586(1).
- [8]S S, Glazier,D M, O'Rourke,D I, Graham,etc.Induction of ischemic tolerance following brief focal ischemia in rat brain.[J].1994,14.
- [9]Kazuo Kitagawa,Masayasu Matsumoto,Masafumi Tagaya,etc.‘Ischemic tolerance’ phenomenon found in the brain[J].1990,528(1).
- [10]D W, Choi.Glutamate neurotoxicity and diseases of the nervous system.[J].1988,1(8).