You Position: Home > Paper
Relationship between the sensitivity to tetraethylammonium and firing patterns of injured dorsal root ganglion neurons
( views:142, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2000.05.009
- Key Word:
- 背根节;自发放电;敏感性;非线性动力学;四乙基胺
Abstract： 为了研究受损背根节神经元的放电型式与其对钾离子通道阻断剂四乙基胺(tetraethylammonium, TEA)反应敏感性的关系, 在大鼠背根节慢性压迫模型上记录单纤维自发放电.这些自发放电有周期和非周期两种型式, TEA (2 mmol/L)分别引起27.3%的周期放电神经元和93.2%的非周期放电神经元的放电增加(P<0.01).非周期放电神经元对不同浓度的TEA的反应均比周期放电神经元大(P<0.01).当5个对TEA 不敏感的周期放电神经元转化为非周期放电后, 对TEA出现明显的反应.在阵发放电中, TEA使非周期性的阵发放电间期明显减小(P<0.01), 而周期性的串放电峰峰间期基本不变(P>0.05).在阵发放电序列中测出非稳定周期轨道, 说明阵发放电中具有确定性混沌.结果表明, 具有混沌特性的非周期放电神经元比周期放电神经元对TEA反应敏感.
- [1]龚璞林,徐健学,龙开平.神经元的确定性与随机性整数倍放电[J].1999,(3).
- [2]Abarbanel HD,Rabinovich MI.The role of chaos in neural systems.[J].1998,87(1).
- [3]M, Devor,W, J?nig,M, Michaelis.Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve-injured rats.[J].1994,71.
- [4]徐晖,胡三觉,韩勇,等.蛋白激酶A介导慢性压迫背根节神经元的肾上腺素能兴奋反应[J].1999,(6).
- [5]Di Matteo-V,Di Mascio-M,Di Giovanni-G,etc.Decreased chaos of midbrain dopaminergic neurons after serotonin denervation.[J].1999,92(1).
- [6]Xu Jianxue,Gong Yunfan,Ren Wei,etc.Propagation of periodic and chaotic action potential trains along nerve fibers[J].1997,100(1-2).
- [7]Jun-Ling Xing,San-Jue Hu.Relationship between calcium-dependent potassium channel and ectopic spontaneous discharges of injured dorsal root ganglion neurons in the rat[J].1999,838(1-2).
- [8]Xing JL,Hu SJ.An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat.[J].1998,77(1).
- [9]Waxman SG,Cummins TR,Dib Hajj-S,etc.Sodium channels and pain.[J].1999,96(14).
- [10]Y, Xie,J, Zhang,M, Petersen,etc.Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat.[J].1995,73.
- [11]P, So,J T, Francis,T I, Netoff,etc.Periodic orbits: a new language for neuronal dynamics.[J].1998,74(6).
- [12]Zhang, X.,Wiesenfeld-Hallin, Z.,Hoekfelt, T..Effect of Peripheral Axotomy on Expression of Neuropeptide Y (NPY) Receptor mRNA in Rat Lumbar Dorsal Root Ganglia[J].1994,6(1).
- [13]R.E. Hoffman,W.X. Shi,B.S. Bunney.Nonlinear sequence-dependent structure of nigral dopamine neuron interspike interval firing patterns[J].1995,69(1).
- [14]Wan YH,Yang HJ,Duan YB,etc.Adrenergic sensitivity of neurons with non-periodic firing activity in rat injured dorsal root ganglion.[J].2000,101(3).
- [15]S. J. Hu,Y. F. Gong,W. Ren,etc.Period-Adding Bifurcation with Chaos in the Interspike Intervals Generated by an Experimental Neural Pacemaker[J].1997,7(8).
- [16]Stollenwerk N.,Sanchezandres JV.,Delaprida LM..Bursting as a Source for Predictability in Biological Neural Network Activity[J].1997,110(3).
- [17]C D, Wagner,P B, Persson.Chaos in the cardiovascular system: an update.[J].1998,40.
- [18]K P, Long,S J, Hu,Y B, Duan,etc.[Pattern and dynamic changes of integer multiples in spontaneous discharge of injured dorsal root ganglion neurons].[J].1999,51(5).