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Nitric oxide changes aortic function in rats with renal hypertension
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.2000.03.015
- Key Word:
- 肾性高血压;一氧化氮;主动脉;卡托普利
Abstract： 探讨一氧化氮(NO)对二肾一夹(2K1C)肾性高血压大鼠主动脉功能的影响.实验分为5组: 假手术、 2K1C、卡托普利(captopril)、 NAME(Nω-Nitro-L-arginine methyl ester)和精氨酸组.结果显示: 在2K1C组, 大鼠手术后4周的平均动脉压显著升高, 主动脉对ACh的舒张反应明显减弱, 对苯肾上腺素的收缩反应明显增强, 主动脉壁环鸟苷酸(cGMP)含量显著减少.卡托普利可完全逆转2K1C组大鼠的上述改变.L-精氨酸能使2K1C大鼠异常的主动脉反应性部分恢复, 主动脉壁的cGMP含量显著升高.用一氧化氮合酶抑制剂L-NAME处理2K1C大鼠, 血压进一步升高, 主动脉对ACh的舒张反应进一步减弱, cGMP含量减少, 而苯肾上腺素的收缩反应未受明显影响.结果提示: 2K1C肾性高血压大鼠的主动脉内皮功能失调与NO生成和释放减少、肾素-血管紧张素系统活性增强有关, 这些因素可能参与2K1C大鼠高血压的发生和维持.
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