You Position: Home > Paper
Increased expression of c-fos in the brainstem nuclei involved in cardiova scular regulation by capsaicin
( views:237, downloads:5 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0371-0874.2000.02.015
- Key Word:
- 辣椒素;钌红;Fos样蛋白;脑干
Abstract： 在16只切断两侧缓冲神经的大鼠, 观察颈总动脉注射辣椒素对脑干内心血管活动相关核团c-fos原癌基因表达的影响.在溶剂对照组大鼠脑干, 仅见少数Fos蛋白样免疫反应(FLI)神经元.与对照组相比, 颈总动脉注射辣椒素(10 μmol, 0.1 ml)时, 脑干内巨细胞旁外侧核(PGL)、蓝斑(LC)、最后区(AP) 和孤束核(NTS)等部位的FLI神经元显著增加, 而中脑中央灰质(PAG)和中缝核群(RN)的FLI神经元则无明显改变.应用辣椒素受体阻断剂钌红(RR;200 mmol, 0.1 ml), 可明显抑制辣椒素的上述效应.以上结果提示, 辣椒素可通过激活辣椒素受体(VR), 引起脑干内多个心血管活动相关核团的神经元兴奋, 但对PAG和RN无影响.
- [1]S, Bevan,J, Szolcsányi.Sensory neuron-specific actions of capsaicin: mechanisms and applications.[J].1990,11(8).
- [2]J S, Clayton,P J, Gaskin,D T, Beattie.Attenuation of Fos-like immunoreactivity in the trigeminal nucleus caudalis following trigeminovascular activation in the anaesthetised guinea-pig.[J].1997,775(1-2).
- [3]F. Michael Cutrer,Volker Limmroth,Gamze Ayata,etc.Attenuation by valproate of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin[J].1995,116(8).
- [4]J I, Morgan,T, Curran.Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.[J].1991,14.
- [5]薛保建,何瑞荣.辣椒素对大鼠延髓腹外侧头端区神经元电活动的影响[J].1999,(6).
- [6]Rainer Amann,Carlo Alberto Maggi.Ruthenium red as a capsaicin antagonist[J].1991,49(12).
- [7]L, Lukovic,W, de Jong,D, de Wied.Cardiovascular effects of substance P and capsaicin microinjected into the nucleus tractus solitarii of the rat.[J].1987,422(2).
- [8]J A, Quest,J, Dias-Souza,W P, Norman,etc.Central nervous system site of action of capsaicin-induced cardiovascular changes in the cat.[J].1984,228.
- [9]G.Jancsó,G.Such.Evidence for a capsaicin-sensitive vasomotor mechanism in the ventral medullary chemosensitive area of the cat[J].1985,329(1).
- [10]Czachurski J,Seller H,Zanzinger J.Activation of chemosensitive neurons in the ventrolateral medulla by capsaicin in cats.[J].1997,226(3).
- [11]D.J. McKitrick,T.L. Krukoff,F.R. Calaresu.Expression of c-fos protein in rat brain after electrical stimulation of the aortic depressor nerve[J].1992,599(2).
- [12]M. HAJÓS,G. JANCSÓ,G. ENGBERG.Capsaicin-induced excitation of locus coeruleus neurons[J].1987,129(3).