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CHANGES OF INHIBITORY AMINO ACID IN THE MONKEY FRONTAL CORTEX DURING A FIGURE RECOGNITION GUIDED SEQUENTIAL MOVEMENT TASK
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0371-0874.1999.06.012
- Key Word:
- 微透析;γ-氨基丁酸;额叶皮层;有序运动;猕猴
Abstract： 本实验采用脑内微透析及高效液相色谱荧光分析技术, 观察了猕猴在执行视觉图形引导的有序运动任务(figure recognition motor sequence, FRS)过程中额叶皮层(前额叶46区, 运动前区的F7和F2区以及初级运动皮层的F1区)透析液中γ-氨基丁酸(GABA) 和甘氨酸(Glycine, Gly)浓度的变化.观察到动物在执行FRS任务时前额皮层透析液中GABA浓度较操作前基础浓度明显升高, 样品配对t-检验具有显著统计意义; Gly浓度也有升高, 但无统计意义.
- [1]陈郁初,黄福德,陈南晖,等.猴运动前区皮层神经元在顺序行为中的放电活动[J].1998,(2).
- [2]U. Halsband,R.E. Passingham.Premotor cortex and the conditions for movement in monkeys (Macaca fascicularis)[J].1985,18(3).
- [3]T, PINTO-HAMUY,P, LINCK.Effect of Frontal Lesions on Performance of Sequential Tasks by Monkeys.[J].1965,12.
- [4]B S, Kolachana,R C, Saunders,D R, Weinberger.In vivo characterization of extracellular GABA release in the caudate nucleus and prefrontal cortex of the rhesus monkey.[J].1997,25(3).
- [5]Kawashima R,Fukuda H,Ito M,etc.PET study of pointing with visual feedback of moving hands.[J].1998,79(1).
- [6]Takao Oishi,Akichika Mikami,Kisou Kubota.Local injection of bicuculline into area 8 and area 6 of the rhesus monkey induces deficits in performance of a visual discrimination GO/NO-GO task[J].1995,22(2).
- [7]M, Weinrich,S P, Wise.The premotor cortex of the monkey.[J].1982,2(9).
- [8]H, Mushiake,M, Inase,J, Tanji.Neuronal activity in the primate premotor, supplementary, and precentral motor cortex during visually guided and internally determined sequential movements.[J].1991,66.
- [9]Massimo Matelli,Giuseppe Luppino,Giacomo Rizzolatti.Patterns of cytochrome oxidase activity in the frontal agranular cortex of the macaque monkey[J].1985,18(2).
- [10]尹萍波,李葆明,叶惟泠,等.延缓go/no-go任务操作中猴尾核兴奋性氨基酸水平变化的微透析研究[J].1997,(2).
- [11]U.HALSBAND,H.FREUND.Premotor Cortex and Conditional Motor Learning in MAN[J].1990,113(1).
- [12]T, Sawaguchi,I, Yamane,K, Kubota.Application of the GABA antagonist bicuculline to the premotor cortex reduces the ability to withhold reaching movements by well-trained monkeys in visually guided reaching task.[J].1996,75.
- [13]L Moll,HG Kuypers.Premotor cortical ablations in monkeys: contralateral changes in visually guided reaching behavior[J].1977,198 (4314).