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DESTRUCTION OF NA INNERVATION IN THE RAT HIPPOCAMPUS RESISTS THE HYPOXIA-INDUCED CORTICOSTERONE SECRETION
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.1999.03.021
- Key Word:
- 低氧;皮质酮;海马;6-羟多巴胺
Abstract： 本工作观察了6-羟多巴胺(6-hydroxydopamine,6-OHDA)损毁大鼠腹侧海马去甲肾上腺素能神经对急性低氧诱发皮质酮分泌的影响.结果显示,吸入10.4% O2 30min后血浆皮质酮水平显著升高,6-OHDA注入腹侧海马致使海马内去甲肾上腺素(NA)含量降低(-38.5%); 血浆皮质酮水平也较未损毁组为低(-33.2%).吸入10.4% O2后,皮质酮对低氧刺激的反应性升高现象消失.结果提示:海马内NA可能参与急性低氧应激引发血浆皮质酮分泌的调节活动.
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