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PROTECTION OF SPINAL MOTORNEURONS OF SECTION SCIATIC NERVE BY TRANSPLANTATION OF NT-4 GENETICALLY EXPRESSION CELLS INTO THE SIDE OF SECTION
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- Author:
- No author available
- Journal Title:
- ACTA PHTYSIOLOGOCA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0371-0874.1999.02.002
- Key Word:
- 神经营养素-4;运动神经元;外周神经损伤
Abstract： 用重组逆转录病毒介导的体外神经营养素-4(NT-4)基因转移方法, 制备高表达NT-4基因工程细胞并移植大鼠坐骨神经离断处.尼氏染色和ChE染色的结果表明, 移植NT-4基因工程细胞对外周神经损伤所造成的运动神经元的退变有显著的改善作用, 而且这种作用可以维持三个月.
- [1]杜卓民.实用组织学技术（第二版）[M].1998.
- [2]H Funakoshi,N Belluardo,E Arenas,etc.Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons[J].1995,268 (5216).
- [3]V E, Koliatsos,M H, Cayouette,L R, Berkemeier,etc.Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons.[J].1994,91.
- [4]R, Levi-Montalcini.The nerve growth factor 35 years later.[J].1987,237(4819).
- [5]Vivien Wong,Ruth Arriaga,Nancy Y. Ip,etc.The Neurotrophins BDNF, NT-3 and NT-4/5, But Not NGF, Up-regulate the Cholinergic Phenotype of Developing Motor Neurons[J].1993,5(5).
- [6]MORRIS J. KARNOVSKY,LOGAN ROOTS.A "Direct-Coloring" Thiocholine Method for Cholinesterases[J].1964,12(3).
- [7]Qiao Yan,Jeffrey L. Elliott,Christine Matheson,etc.Influences of neurotrophins on mammalian motoneuronsin vivo[J].1993,24(12).
- [8]Finn Hallböök,Carlos F. Ibáñez,Håkan Persson.Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary[J].1991,6(5).
- [9]Kleinfeld D,Liu L,Verge VM,etc.BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons.[J].1995,15(2).