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EFFECTS OF GLYCINE AND STRYCHNINE MICROINJECTED INTO UNILATERAL AND BILATERAL B(o)tzinger COMPLEX ON PHRENIC NERVE DISCHARGES IN RABBITS
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0371-0874.1998.06.015
- Key Word:
- B(o)tzinger复合体;膈神经放电;微量注射;甘氨酸;士的宁
Abstract： 实验在34只氨基甲酸乙酯麻醉、断双侧颈迷走神经、肌松、人工通气的家兔上进行.单侧和双侧B(o)tzinger复合体(B(o)t.C)内微量注射抑制性神经递质甘氨酸及其受体阻断剂士的宁,观察膈神经放电的变化.结果如下:(1)单侧注射甘氨酸使呼吸频率增加,呼气相膈神经出现放电活动;(2)双侧B(o)t.C注射甘氨酸后呼气相消失,膈神经呈无节律紧张性放电,幅度为前对照吸气放电幅度的40%～70%.士的宁能竞争性阻断甘氨酸的效应;(3)双侧B(o)t.C注射士的宁后,呼吸频率减慢,呼气时程延长,膈神经放电幅度降低,吸气时程无明显变化.上述结果提示:B(o)t.C在呼气相的形成和维持中起关键作用.
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