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EFFECTS OF ENDOTHELIN ON CAROTID BARORECEPTOR ACTIVITITY IN ANESTHETIZED RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.1998.05.009
- Key Word:
- 内皮素;压力感受器活动;窦神经传入放电;ATP敏感性钾通道
Abstract： 在麻醉大鼠隔离灌流颈动脉窦区条件下记录窦神经传入放电,观察内皮素(ET-1)对动脉压力感受器活动的影响.结果如下:(1)在颈动脉窦区灌流1 nmol/L ET-1时,压力感受器机能曲线向左上方移位,曲线的最大斜率(PS)增加,窦神经传入放电最大积分值(PIV)增大.由此提示,这一剂量的ET-1对压力感受器活动有易化作用.(2)用10 nmol/L ET-1灌流时,压力感受器机能曲线则向右下方移位,PS降低,PIV减小;100 nmol/L ET-1则使压力感受器机能曲线向右下方移位更为明显,PS及PIV降低更加明显.这些结果表明,上述两剂量的ET-1对压力感受器活动有抑制作用.(3)ETA受体选择性阻断剂BQ-1123(0.15μmol/L)可阻断10 nmol/L ET-1对压力感受器活动的抑制效应.(4)预先灌流KATP通道阻断剂格列苯脲(10umol/L),也可阻断ET-1的抑制效应.综上所述,ET-1对压力感受器活动有双重效应,低剂量时有易化作用,而较高剂量时则有抑制作用,后一作用由ETA型受体介导并有KATP通道的参与.
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