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REGULATION OF ACTH4-9 ANALOGUE ON THE Ca2+ LEVEL OF MOUSE HIPPOCAMPAL SYNAPTOSOMES

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Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
4
DOI:
10.3321/j.issn:0371-0874.1998.04.014
Key Word:
Org2766;海马突触体;Fura-2;[Ca2+]i;45Ca2+摄取

Abstract: 本工作观察了Org2766(ACTH4-9的类似物)对海马突触体内游离Ca2+水平及对45Ca2+摄取的影响.采用细胞内钙离子荧光探针Fura-2,通过Spex-阳离子测定系统检测突触体内[Ca2+]i的动态变化,并用液闪光谱仪测定突触体对45Ca2+的摄取.结果表明:较低剂量的Org2766对突触体内[Ca2+]i的影响不明显,却显著降低突触体对45Ca2+的摄取;高剂量的Org2766增加突触体内[Ca2+]i,但对突触体的45Ca2+摄取无影响.较低剂量的Org2766可拮抗茴香霉素(ANI)升高突触体内[Ca2+]i和45Ca2+摄取量的作用,高剂量的Org2766无此效应.此结果提示,Org2766可通过抑制胞外钙内流和增加胞内钙库的释放来调节胞内钙水平.

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