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THE CENTRAL MECHANISM OF THE HIGH FREQUENCY COMPONENT IN HEART RATE VARIABILITY IN RAT
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.1998.04.006
- Key Word:
- 大鼠;心率变异性;神经元放电变异性;疑核;谱分析;延髓头端腹外侧区
Abstract： 本文探讨心率变异性(heart rate variability,HRV)频谱中高频成分的中枢机理.对正常SD大鼠给予不同频率的人工通气并电刺激延髓疑核,观察HRV频谱的改变,记录与呼吸节律同步的延髓头端腹外侧区(rostral ventrolateral medulla,rVLM)及其周围区神经元细胞外单位放电,对HRV和放电变异性进行相干函数分析.结果显示:(1)HRV的高频成分的中心频率随着人工通气频率的增加而增加,呈高度线性相关,(r=0.83,P＜0.0001);(2)对rVLM及其周围区与呼吸节律同步的神经元细胞外单位放电和HRV同时进行频谱分析,两者的高频峰呈良好的相关,相干系数k2=0.854±0.1;(3)间断电刺激延髓疑核时,HRV高频成分显著增加.实验直接提示rVLM区参与对HRV的高频调节,HRV的高频成分反映了迷走中枢的波动性活动.
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