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THE EFFECT OF LYCIUM BARBARUM POLYSACCHARIDE ON VASCULAR TENSION IN TWO-KIDNEY,ONE CLIP MODEL OF HYPERTENSION
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.1998.03.011
- Key Word:
- 枸杞多糖;高血压;内皮;内皮舒张因子
Abstract： 本工作利用两肾一夹(2K1C)肾性高血压(RH)大鼠模型,观察枸杞多糖(LBP)对高血压大鼠血压的影响以及离体主动脉环内皮细胞在调节血管张力中的功能改变,探讨LBP对高血压发生发展的影响及其机制.结果表明,LBP可防止2K1C大鼠高血压的形成.离体主动脉环灌流表明RH组对苯肾上腺素(PE)的收缩反应明显高于对照组,去除内皮后组间差异消失;而LBP组由一氧化氮(NO)合成酶抑制剂N-硝基-L-精氨酸甲基酯(L-NAME)及鸟苷酸环化酶抑制剂美蓝(MB)引起的收缩反应较RH组明显增加;LBP组对乙酰胆碱(ACh)的内皮依赖性舒张反应较RH对照组明显增加,而对非内皮依赖舒张剂硝普钠(SNP)的舒张反应无组间差异;NO合成底物L-精氨酸(L-Arg)能显著提高RH大鼠对ACh的内皮依赖性舒张,而对LBP组元明显作用.上述结果表明,LBP降低2K1C大鼠增强的血管收缩反应,增加内皮依赖性的舒张.此作用与LBP对内皮的保护、内皮源性舒张因子(EDRF)生成增多以及促进L-Arg的代谢有关.
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