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Research progress on scleral remodeling and scleral intervention in ocular diseases

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Author:: No author available

Journal Title:: International Eye Science

Issue:: 12

DOI:: 10.3980/j.issn.1672-5123.2022.12.15

Key Word:: 巩膜生物力学;细胞外基质;巩膜重塑;巩膜干预;眼部疾病

Abstract：巩膜是维持眼球结构和功能的重要组织,其特有的生物力学特性能影响眼部疾病的发生和发展.巩膜生物力学特性主要由巩膜细胞外基质(ECM)决定.巩膜ECM包含不同类型胶原纤维、蛋白聚糖及其他物质.在眼部疾病中,巩膜ECM成分的含量或排布会发生变化,巩膜生物力学也相应改变,这一系列的过程可称为巩膜重塑(scleral remodeling).近年来研究表明,在许多眼部疾病中,巩膜重塑是一个复杂且动态的过程,而许多关键信号分子及通路已被证实参与并调控这一过程.本文就目前影响眼部疾病中巩膜重塑的关键信号分子及通路进行综述,并探究巩膜干预在治疗眼部疾病中的可能性.

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