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Dexamethasone intravitreal implant in the treatment of diabetic macular edema

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Author:: No author available

Journal Title:: International Eye Science

Issue:: 12

DOI:: 10.3980/j.issn.1672-5123.2022.12.11

Key Word:: 地塞米松玻璃体内植入剂;糖尿病性黄斑水肿;炎症;有效性;安全性

Abstract：糖尿病性黄斑水肿(DME)是糖尿病患者视力丧失的主要原因.高血糖通过引发促炎和促血管生成级联反应致血-视网膜屏障破坏,导致黄斑区视网膜内或视网膜下液体积聚.玻璃体内注射类固醇是DME的替代治疗方法,而注射相关的并发症包括眼内炎、玻璃体出血和视网膜脱离.为了减少风险和并发症,地塞米松玻璃体内植入剂(DEX植入剂;Ozurdex?)应运而生.DEX植入剂是一种新型、可人工降解的缓释植入剂,具有合理释放曲线、强力抗炎、快速改善黄斑水肿、良好的生物利用度及安全性等优势.DEX植入剂为DME患者的治疗提供了新的选择,已被多个指南推荐使用.本文就其在DME临床治疗中的研究进展进行简要综述.

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