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Research progress of Mingmu-11 and its active ingredients for the treatment of diabetic macular edema

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Author:: No author available

Journal Title:: International Eye Science

Issue:: 12

DOI:: 10.3980/j.issn.1672-5123.2022.12.10

Key Word:: 民族医学;明目-11;糖尿病性黄斑水肿;藏红花;姜黄素

Abstract：糖尿病性黄斑水肿(DME)是糖尿病威胁视力的一种眼部并发症,是成人失明的重要原因.当前,中国有糖尿病患者1.41亿,伴随糖尿病患病人数的增长,DME的发病率也在逐年攀升.现代医学对DME的治疗取得了一定效果,但副作用明显,且有局限性.明目-11是我院眼科临床应用较为广泛的治疗糖尿病视网膜病变的有效方剂,包含了藏花醛、藏红花酸、姜黄素、没食子酸、鞣花酸、山奈酚、香草醛等生物活性成分.明目-11相关实验研究和临床应用报告显示,该药对DME的神经损害、缺血再灌注损伤、炎症、氧化损伤、微血管损害及渗漏等具有保护作用,可延缓糖尿病视网膜病变(DR)的进展.本文从DME的发病机制、明目-11及其活性成分对DME的治疗作用等方面进行论述.

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