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Involvement of STING signaling pathway in non-alcoholic fatty liver disease

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 24

DOI:: 10.11569/wcjd.v29.i24.1396

Key Word:: 非酒精性脂肪性肝病;免疫;STING;信号通路

Abstract：非酒精性脂肪肝疾病(non-alcoholic fatty liver disease,NAFLD)是全球范围内的主要慢性肝病之一,严重威胁人类健康,已成为一个重大的公共卫生问题.免疫机制在NAFLD的发生发展中起着关键作用.干扰素基因刺激因子(interferon gene stimulating factor,STING)是机体免疫系统的一个关键性接头蛋白,其相关信号通路作为新近的一个研究热点,可能通过介导肝脏炎症、脂质代谢以及细胞凋亡等过程影响肝脏的代谢稳态从而参与NAFLD的发生发展.本文结合相关报道和最新文献,从NAFLD与免疫、STING信号通路的组成以及STING信号通路与NAFLD之间的关系三方面做了一综述,以期为进一步深入的研究STING信号通路与NAFLD之间的复杂关系以及开发相关靶向药物提供帮助和思路.

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