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Research development and potential therapeutic value of m6A modification in occurrence and progression of colorectal tumors

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 23

DOI:: 10.11569/wcjd.v29.i23.1373

Key Word:: m6A甲基化;表观遗传修饰;结直肠肿瘤;靶向治疗

Abstract：近年来,作为表观遗传修饰的重要组成部分,DNA组学和蛋白质组学在肿瘤发生发展中的作用机制研究已取得一定突破,而研究者也将目光聚焦在RNA的修饰上.N6-甲基腺嘌呤(N6-methyladenosine,m6A)是真核生物mRNA中主要的内部表观遗传修饰,具有动态且可逆的特点.m6A分别受到甲基化酶(Writers)、去甲基化酶(Erasers)和优先识别m6A修饰的蛋白质(Readers)调控,进一步调节RNA运输、定位、翻译及降解等,在肿瘤的发生发展中发挥促癌或抑癌的作用,并且具有成为恶性肿瘤治疗靶点的潜力.本文将对m6A的生物学特征、m6A RNA的修饰调控机制、m6A RNA甲基化修饰在结直肠肿瘤发生发展中的作用和相关靶向治疗进行综述,旨在为进一步寻找生物标记物和治疗靶点提供依据.

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