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Research progress of circRNAs in chemotherapy resistance of digestive system neoplasms

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 21

DOI:: 10.11569/wcjd.v29.i21.1237

Key Word:: 环状RNAs;竞争性内源RNA;化疗耐药;消化系肿瘤

Abstract：环状RNA (circRNAs)是一类具有独立闭合环状结构的新型非编码RNA.circRNAs在真核细胞中含量丰富,具有独特的稳定性和组织特异性,可以在转录和转录后水平上发挥生物调节作用.越来越多的证据表明,circRNAs在肿瘤的发生、发展以及化疗耐药中起着至关重要的作用.化疗是大多数消化系肿瘤的主要治疗手段,它们的治疗效果常受到固有和获得性耐药的影响.circRNAs主要通过影响细胞凋亡、促进药物转运、促进DNA修复、促进上皮-间充质转化、调控肿瘤干细胞特性、影响自噬等多种机制调控肿瘤化疗耐药.本文综述了circRNAs在消化系肿瘤化疗耐药中的最新研究进展及其机制,并探讨了其潜在的临床应用前景.

Reference

[1]Xueping Tao,Yongfu Shao,Jianing Yan,etc.Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies[J].2021,(2).
[2]DONG Li,YAN Yang,Ze-Qin Li,etc.Circular RNAs: from biogenesis and function to diseases[J].2019,(20).
[3].Hsa_circ_0001546 acts as a miRNA-421 sponge to inhibit the chemoresistance of gastric cancer cells via ATM/Chk2/p53-dependent pathway[J].2020,521(2).
[4]Yan-Yan,Liu,Li-Ying,Zhang,Wen-Zhen,Du.Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through the regulation of ZEB1 expression by sponging miR-124-3p.[J].2019,39(12).
[5]Hansen Thomas B.,Jensen Trine I.,Clausen Bettina H.,etc.Natural RNA circles function as efficient microRNA sponges[J].2013,495(7441).
[6]Wang, Xiaojie,Zhang, Ying,Li, Wei,etc.Knockdown of cir_RNA PVT1 Elevates Gastric Cancer Cisplatin Sensitivity via Sponging miR-152-3p[J].2021,261.
[7]Xiaoxu,Huang,Zheng,Li,Qiang,Zhang,etc.Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression.[J].2019,18(1).
[8]Li Xiaomin,He Jiefeng,Ren Xiaojing,etc.Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway[J].2020,15(1).
[9]Ju Dong Yang,Pierre Hainaut,Gregory J Gores,etc.A global view of hepatocellular carcinoma: trends, risk, prevention and management.[J].2019,16(10).
[10]Nagler Arnon,Labopin Myriam,Houhou Mohamed,etc.Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplanta[J].2021,14(1).
[11]Feng, W.,Xiaoyan, X.,Xuan, Y.,etc.Silencing stathmin-modulating efficiency of chemotherapy for esophageal squamous cell cancer with paclitaxel[J].2015,22(3).
[12]Jin,Li,Xiaoping,Qin,Ruishan,Wu,etc.Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1 axis.[J].2020,24(9).
[13]Bakir, Basil,Chiarella, Anna M.,Pitarresi, Jason R.,etc.EMT, MET, Plasticity, and Tumor Metastasis[J].2020,30(10).
[14]Naifei,Chen,Gang,Zhao,Xu,Yan,etc.A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.[J].2018,19(1).
[15]Xiao-Ou Zhang,Hai-Bin Wang,Yang Zhang,etc.Complementary Sequence-Mediated Exon Circularization[J].2014,159(1).
[16]Zhong, Yanmei,Wang, Dan,Ding, Yanle,etc.Circular RNA circ_0032821 contributes to oxaliplatin (OXA) resistance of gastric cancer cells by regulating SOX9 via miR-515-5p[J].2021,43(2).
[17]Liu Yong,Xu Jianzhong,Jiang Min,etc.CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis[J].2020,20(1).
[18]Kun-I,Lin,Jia-Lian,Yang,Yu-Chao,Lin,etc.Network Meta-Analysis of Efficacy and Safety of Chemotherapy and Target Therapy in the First-Line Setting of Advanced Pancreatic Cancer.[J].2019,11(11).
[19]Li Jie,Xu Qiang,Huang Zi-jian,etc.CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms[J].2021,12(2).
[20]Zhang,Y.,Zhang,X.-O.,Chen,T.,etc.Circular Intronic Long Noncoding RNAs[J].2013,51(6).
[21]Wu Xiaomin,Ma Guang,Liu Chuanyang,etc.Biosynthesis of pinene in purple non-sulfur photosynthetic bacteria[J].2021,20(1).
[22]Q-Y,Xu,M-J,Xie,J,Huang,etc.Effect of circ MTHFD2 on resistance to pemetrexed in gastric cancer through regulating expression of miR-124.[J].2019,23(23).
[23].A philosophical case for big physics[J].2021,17(6).
[24]El Serag HB.Hepatocellular carcinoma.[J].2011,365(12).
[25]Mingfen,Lai,Guiju,Liu,Ruijun,Li,etc.Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF-α pathway in human colon cancer.[J].2020,24(9).
[26]Sanger H. L.,Klotz G.,Riesner D.,etc.Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures.[J].1976.
[27]Guangsong,Xu,Mingliang,Li,Jiang,Wu,etc.Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1α-Dependent Glucose Metabolism in Gastric Carcinoma.[J].2020,12.
[28]Nobili, Stefania,Lapucci, Andrea,Landini, Ida,etc.Role of ATP-binding cassette transporters in cancer initiation and progression[J].2020,60.
[29]Kuang-Ming, Liao,Tung-Bo, Chao,Yu-Feng, Tian,etc.Overexpression of the PSAT1 Gene in Nasopharyngeal Carcinoma Is an Indicator of Poor Prognosis.[J].2016.
[30]Ceccaldi, Raphael,Rondinelli, Beatrice,D'Andrea, Alan D..Repair Pathway Choices and Consequences at the Double-Strand Break[J].2016,26(1).
[31]Chen, Ling-Ling.The biogenesis and emerging roles of circular RNAs[J].2016,17(4).
[32]Pamudurti, Nagarjuna Reddy,Bartok, Osnat,Jens, Marvin,etc.Translation of CircRNAs[J].2017,66(1).
[33]In-Hye,Ham,Hye Jeong,Oh,Hyejin,Jin,etc.Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer.[J].2019,18(1).
[34]Aufiero, Simona,van den Hoogenhof, Maarten M. G.,Reckman, Yolan J.,etc.Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons[J].2018,24(6).
[35]Kalyan, Aparna,Nimeiri, Halla,Kulik, Laura.Systemic Therapy of Hepatocellular Carcinoma Current and Promising[J].2015,19(2).
[36]Gustavsson, Bengt,Carlsson, Goran,Machover, David,etc.A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer[J].2015,14(1).
[37]Yanwei,Luo,Yunfeng,Fu,Rong,Huang,etc.CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression.[J].2019,5.
[38]Peng Lei,Sang Huaiming,Wei Shuchun,etc.circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2[J].2020,19(1).
[39]Arnold, Melina,Soerjomataram, Isabelle,Ferlay, Jacques,etc.Global incidence of oesophageal cancer by histological subtype in 2012[J].2015,64(3).
[40]Xu Junjie,Ji Lin,Liang Yuelong,etc.CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1[J].2020,5(1).
[41]Ester,Oneda,Alberto,Zaniboni.Are We Sure that Adjuvant Chemotherapy is the Best Approach for Resectable Pancreatic Cancer? Are We in the Era of Neoadjuvant Treatment? A Review of Current Literature.[J].2019,8(11).
[42]Ma Ling,Wang Zhangding,Xie Mengyan,etc.Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7[J].2020,11(3).
[43]Zhai, Jing,Shen, Jiajia,Xie, Guiping,etc.Cancer-associated fibroblasts-derived IL-8 mediates resistance to cisplatin in human gastric cancer[J].2019,454.
[44]Qu Fanyong,Wang Lina,Wang Caiyan,etc.Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis[J].2021,21(1).
[45]Hang,Chen,Shan,Liu,Molin,Li,etc.circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/β-Catenin Pathway In Hepatocellular Carcinoma.[J].2019,12.
[46]Wang Jiaqi,Zhang Yi,Song Hu,etc.The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway[J].2021,20(1).
[47]Chen, Jiang,Jin, Renan,Zhao, Jie,etc.Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma[J].2015,367(1).
[48]Melin Nicolas,Sánchez-Taltavull Daniel,Fahrner René,etc.Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury[J].2021,12(4).
[49]Xinyi,Wang,Haiyang,Zhang,Haiou,Yang,etc.Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer.[J].2020,14(3).
[50]Peng Deng,Ming Sun,Wen-Yan Zhao,etc.Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis[J].2021,(6).
[51]Abnet, Christian C.,Arnold, Melina,Wei, Wen-Qiang.Epidemiology of Esophageal Squamous Cell Carcinoma[J].2018,154(2).
[52]Legnini, Ivano,Di Timoteo, Gaia,Rossi, Francesca,etc.Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis[J].2017,66(1).
[53]Zhu, Han,Du, Fang,Cao, Chenghua.Restoration of circPSMC3 sensitizes gefitinib-resistant esophageal squamous cell carcinoma cells to gefitinib by regulating miR-10a-5p/PTEN axis[J].2021,45(1).
[54].Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance[J].2020,12(3).
[55]Blanche Capel,Amanda Swain,Silvia Nicolis,etc.Circular transcripts of the testis-determining gene Sry in adult mouse testis[J].1993,73(5).