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Research progress of non-steroidal anti-inflammatory drug-induced small intestinal injury

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 20

DOI:: 10.11569/wcjd.v29.i20.1191

Key Word:: 非甾体抗炎药;小肠损伤;干预治疗

Abstract：非甾体类抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)是一种抗炎镇痛及抗血小板药物,在全世界被广泛使用.但随着NSAIDs的长期应用,其并发症逐渐受到人们的关注.以往在临床上关注较多的是其导致的上消化道并发症,但随着内窥镜如胶囊内镜和双气囊小肠镜等的普及,人们发现NSAIDs引起的小肠损伤也并不少见.虽然大部分患者并无明显症状,但仍有部分患者出现了明显的症状或复杂的溃疡,需要进行治疗干预.然而,针对NSAIDs相关性肠病的药物尚未被研发,因此,进一步研究NSAIDs相关肠病的发病机制并制定合适的防治策略是有必要的.本文对NSAIDs所致小肠损伤的流行病学、临床表现、诊断、危险因素、发病机制和治疗进行了归纳总结,为NSAIDs的使用及其并发症的防治提供参考.

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