Prognostic role of HOTAIR in colorectal cancer:A meta-analysis
- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 17
- DOI:
- 10.11569/wcjd.v29.i17.984
- Key Word:
- HOX转录反义RNA;HOTAIR;结直肠癌;Meta分析
Abstract： 背景结直肠癌是最常见的恶性肿瘤之一,能够找到早期发现和评估肿瘤预后的生物标志物十分必要.近年来研究发现,HOX转录反义RNA(HOX transcript antisense RNA,HOTAIR)在包括结直肠癌的各种癌症中表达升高,但由于各个研究样本量较小,说服力不强.目的 采用Meta分析的方法对HOTAIR表达水平与结直肠癌患者预后的关系进行探讨.方法 通过对PubMed、Medline、CNKI、CBM和Cochrane图书馆的搜索,检索2020-12发表的有关HOTAIR表达水平与结直肠癌患者预后关系的文献.两名评价员独立进行纳入文献的质量评价和数据提取,计算总生存期(overall survival,OS)的危险比(hazard ratio,HR)以及淋巴结转移(lymph node metastasis,LNM)和远处转移(distant metastasis,DM)的优势比(odds ratios,OR),以评估关联强度.结果 符合纳入标准的7篇文献被纳入.其中6篇比较了HOTAIR袁达水平与OS的相关性,结果显示两组间差异有统计学意义(OR=2.36,95％CI:1.74-3.19,P＜0.05).5篇比较了HOTAIR表达水平与LNM的相关性,两组间差异有统计学意义(OR=4.07,95％CI:1.38-12.0,P＜0.05).4篇比较了HOTAIR表达水平与DM的相关性,两组间差异有统计学意义(OR=4.32,95％CI:1.60-11.62,P＜0.05).结论 结直肠癌组织中HOTAIR的高表达与OS降低和LNM、DM有显著的相关性,提示HOTAIR有可能作为一种判断肿瘤预后的新型生物标志物,对结直肠癌患者的预后监测具有一定的意义.
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