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Relationship of expression of heat shock transcription factor 1 with sensitivity to radiotherapy and chemotherapy in esophageal squamous cell carcinoma

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 14

DOI:: 10.11569/wcjd.v29.i14.775

Key Word:: 热休克转录因子1;食管鳞状细胞癌;放疗;化疗;敏感性

Abstract：背景食管癌发病率及死亡率在全世界都极高,且治疗效果不佳.由于目前对食管癌发病机制尚未完全清楚,这不利于食管癌特异性治疗药物的研究.通过阅读大量文献发现,热休克转录因子1(heat shock transcription fact 1,HSF1)与多种恶性肿瘤的发生发展密切相关,那么HSF1是否也与食管鳞状细胞癌的发生发展密切相关呢?HSF1是否会成为治疗食管鳞状细胞癌的生物靶标呢?在不同中晚期食管鳞状细胞癌患者中,不同患者对放化疗敏感度不一样,已有研究证明,在肝细胞癌中,H S F1会削弱放化疗对肿瘤的毒性作用从而降低疗效,那么HSF1是否会影响食管鳞状细胞癌对放化疗的敏感性呢?目的探究HSF1在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中表达情况及其表达程度对ESCC放化疗敏感性的影响.方法(1)将92例患者分成4组:ESCC Ⅰ、Ⅱ期手术切除组20例,ESCC Ⅲ、Ⅳ期手术切除组18例,ESCC Ⅲ、Ⅳ期放化疗组44例,其中ESCC Ⅲ、Ⅳ期放化疗组分为HSF1低表达组16例和高表达组28例食管不典型增生组10例;对照组:食管炎症组10例;(2)取各组病理蜡块通过免疫组化及染色技术检测HSF1在各组表达情况;(3)通过ESCC Ⅲ、Ⅳ期患者HSF1低表达组及高表达组的非肿瘤病灶大小、肿瘤直径及癌胚抗原(carcinoembryonic antigen,CEA)值在放化疗前后的变化,评估患者对放化疗治疗敏感性;(4)分析影响ESCC手术患者3年生存期的相关因素及ESCC患者3年总体生存率.结果(1)HSF1在各ESCC组中高表达,在食管炎症组及食管不典型增生组中低表达,且各ESCC组与食管炎症组及食管不典型增生组的HSF1表达情况存在差异,P=0.001,有统计学意义;HSF1表达与年龄、性别、肿瘤部位、肿瘤大小、分化程度、T分期、N分期、M分期无关,P＞0.05,均无统计学意义;(2)放化疗后,ESCC Ⅲ、Ⅳ期放化疗组中HSF1低表达组与HSF1高表达组相比,非肿瘤病灶减少更多,肿瘤直径减小更大,CEA值下降更明显,P＜0.005,均有统计学意义;(3)在ESCC手术切除组中,3年生存期与年龄(P=0.019)、HSF1表达程度(P=0.028)、T分期(P=0.007)、N分期(P=0.016)有关,均有统计学意义,与性别、肿瘤部位、肿瘤大小、分化程度无关,P＞0.05,均无统计学意义;HSF1低表达组3年总体生存率比HSF1高表达组高,P=0.016,有统计学意义;(4)在ESCC Ⅲ、Ⅳ期放化疗组中,HSF1低表达组1年、2年及3年生存率均比HSF1高表达组高,P＜0.05,有统计学意义;HSF1低表达组3年总体生存率比HSF1高表达组高,P=0.03,有统计学意义.结论(1)HSF1在ESCC中高表达且HSF1表达越高,患者预后越差,且HSF1表达与患者临床特征无关;(2)在ESCC Ⅲ、Ⅳ期放化疗组中,HSF1表达越高,患者对放化疗敏感性越差;(3)在ESCC手术切除组及ESCC Ⅲ、Ⅳ期放化疗组中,HSF1低表达组3年总体生存率比HSF1高表达组高.

Reference

[1]王树党.图像分析系统中光度学参数--灰度与光密度的应用[J].2003,(5).
[2]Yesim, G?kmen-Polar,Sunil, Badve.Upregulation of HSF1 in estrogen receptor positive breast cancer.[J].2016,(51).
[3]Lin,Wang,G.,etc.Heat Shock Factor 1 in Relation to Tumor Angiogenesis and Disease Progression in Patients With Pancreatic Cancer[J].2020,49(10).
[4]Gautam K. Malhotra,Ujwal Yanala,Advaitaa Ravipati,etc.Global trends in esophageal cancer[J].2017,115(5).
[5]María José Domper Arnal,ángel Ferrández Arenas,ángel Lanas Arbeloa.Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries[J].2015,(26).
[6]Tao Wan,Jing Shao,Bin Hu,etc.Prognostic role of HSF1 overexpression in solid tumors: a pooled analysis of 3,159 patients.[J].2018,11.
[7]Janardhan Kyathanahalli S.,Jensen Heather,Clayton.Immunohistochemistry in Investigative and Toxicologic Pathology[J].2018,46(5).
[8]Nan Zhang,Yaran Wu,Xilin Lyu,etc.HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells[J].2017,409.
[9]Xing-Wen,Fan,Jun-Lan,Wu,Hong-Bing,Wang,etc.Three-dimensional conformal radiation therapy alone for esophageal squamous cell carcinoma: 10-year survival outcomes.[J].2019,10(3).
[10]Fei Yang,Shiwang Wen,Yuefeng Zhang,etc.Identifying potential metastasis‐related long non‐coding RNAs, microRNAs, and message RNAs in the esophageal squamous cell carcinoma[J].2019,120(8).
[11]Liang Wenjin,Liao Yong,Zhang Jing,etc.Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis[J].2017,36(1).
[12]B,Babic,H F,Fuchs,C J,Bruns.[Neoadjuvant chemoradiotherapy or chemotherapy for locally advanced esophageal cancer?][J].2020,91(5).
[13]Tian, Wenze,Jiang, Chao,Huang, Ziming,etc.Comprehensive analysis of dysregulated lncRNAs, miRNAs and mRNAs with associated ceRNA network in esophageal squamous cell carcinoma[J].2019,696.
[14]Zhou, Zhenhua,Li, Yan,Jia, Qi,etc.Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells[J].2017,50(4).
[15]Whitesell, L.,Schnitt, S.J.,Santagata, S.,etc.High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer[J].2011,108(45).
[16]Short, Matthew W.,Burgers, Kristina G.,Fry, Vincent T..Esophageal Cancer[J].2017,95(1).
[17].MiR-495 inhibits esophageal squamous cell carcinoma progression by targeting Akt1.[J].2016,(32).
[18]Chun Yan Wang,Su Tang Guo,Amanda Croft,etc.BAG3‐dependent expression of Mcl‐1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922[J].2018,57(2).
[19]Sinha, S.,Varagunam, M.,Park, M. H.,etc.Brachytherapy in the Palliation of Oesophageal Cancer: Effective but Impractical?[J].2019,31(7).
[20]Alicia S. Borggreve,B. Feike Kingma,Serg A. Domrachev,etc.Surgical treatment of esophageal cancer in the era of multimodality management[J].2018,1434(1).
[21]Weigang,Dai,Jinning,Ye,Zhimei,Zhang,etc.Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients.[J].2018,13(1).
[22]Qiao Wei,Xiyi Li,Weiwei Yu,etc.microRNA‐messenger RNA regulatory network of esophageal squamous cell carcinoma and the identification of miR‐1 as a biomarker of patient survival[J].2019,120(8).
[23]Tsukao, Yukiko,Yamasaki, Makoto,Miyazaki, Yasuhiro,etc.Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma[J].2017,13(3 Pt.B).
[24]Xiaoyan,Li,Changjun,Nie,Baoqing,Tian,etc.miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2.[J].2019,15(9).
[25]Zhang J-B,Guo K,Sun H-C,etc.Prognostic value of peritumoral heat-shock factor-1 in patients receiving resection of hepatocellular carcinoma[J].2013,109(6).
[26]Skjefstad Kaja,Johannessen Charles,Grindstad Thea,etc.A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer[J].2018,8(1).
[27]Yu, Jun,Wu, Xiaoliu,Huang, Kaidan,etc.Bioinformatics identification of lncRNA biomarkers associated with the progression of esophageal squamous cell carcinoma[J].2019,19(6 Pt.B).
[28]Cui, Jingjing,Tian, Hui,Chen, Guanqing.Upregulation of Nuclear Heat Shock Factor 1 Contributes to Tumor Angiogenesis and Poor Survival in Patients With Non-Small Cell Lung Cancer[J].2015,100(2).
[29]Dong, Bushu,Jaeger, Alex M.,Thiele, Dennis J..Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity[J].2019,40(12).
[30]Cheng-Yun,Li,Wen-Wen,Zhang,Ji-Lian,Xiang,etc.Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma.[J].2019,42(6).
[31]Yuehua, Liao,Ying, Xue,Lin, Zhang,etc.Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients.[J].2015,13.