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Effects of interaction between mesenchymal stem cells and gut microbiota in treatment of inflammatory bowel disease

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 6

DOI:: 10.11569/wcjd.v29.i6.312

Key Word:: 炎症性肠病;肠道菌群;间充质干细胞;肠黏膜上皮

Abstract：炎症性肠病(inflammatory bowel diseases,IBD)是一种慢性复发性非特异性肠道疾病,其病因和发病机制尚未完全阐明.研究证实肠道菌群与肠粘膜之间异常的免疫调控在IBD的发生发展中起着决定性作用,纠正菌群失调的肠道微生态疗法对IBD的治疗有着重要的临床意义.间充质干细胞(mesenchymal stem cells,MSCs)在IBD的应用中显示出积极的治疗前景,其有望成为IBD的新兴治疗手段.MSCs除了免疫抑制、组织修复的作用以外,还有助于恢复正常肠道菌群的多样性及丰度,同时,肠道菌群对MSCs的功能活动同样起着重要的调控作用.因此在IBD的环境背景下,MSCs与肠道微生态疗法的联合应用可能会取得更好的临床治疗效果.本文就IBD肠道菌群特征及菌群靶向治疗现状,肠道菌群与宿主肠粘膜上皮之间以及MSCs与肠道菌群之间的相互调控关系在IBD治疗中的作用做一综述,可为探究MSCs-肠道菌群相互作用提供重要指导意义.

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