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Update on pharmacotherapy of hepatic encephalopathy

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 2

DOI:: 10.11569/wcjd.v29.i2.58

Key Word:: 肝性脑病;药物治疗;高血氨;星形胶质细胞

Abstract：肝性脑病(hepatic encephalopathy,HE)系由肝功能不全和/或门体分流引起的,因体内代谢紊乱而导致的中枢神经系统疾病.HE的发病机制和病理生理至今仍未完全阐明,最为核心的仍然是20世纪30年代提出的氨中毒学说.因此,目前HE的药物治疗采用的是以降氨为主,辅以神经系统改善的策略.同时,随着近年来对于氨诱导脑细胞损伤机理的揭示,研究人员又发现了一些新的HE治疗靶点和相关药物.本文将从降氨、神经系统改善、干预氨毒性靶点三个方面,对于目前HE治疗药物的进展做一简单总结.

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