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Intestinal microflora in metabolic diseases

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 23

DOI:: 10.11569/wcjd.v28.i23.1192

Key Word:: 代谢性疾病;肠道菌群;肥胖;糖尿病;非酒精性脂肪肝

Abstract：代谢性疾病是指葡萄糖、蛋白质及脂质在体内代谢异常引起的一类疾病.越来越多的证据支持肠道菌群失调与代谢性疾病具有重要的相关性.具体而言,肠道菌群失调可能破坏肠道屏障功能,诱发内毒素血症、胆汁酸代谢紊乱和全身慢性低度炎症,促进代谢性疾病进展及并发症发生.随着代谢性疾病病情进展,肠道内环境改变以及药物、饮食等影响又反过来加重肠道菌群失调,最终引起预后不良.这凸显了通过调节肠道菌群结构来开发防治代谢性疾病治疗策略的可能性.益生菌、益生元和合生元疗法、粪菌移植、中医药等可通过维持肠道菌群平衡、对抗有害菌群产物,从而治疗代谢性疾病.本文从代谢性疾病肠道菌群变化、肠道菌群影响代谢性疾病的可能机制、肠道菌群在代谢性疾病治疗中的应用等方面进行综述,以期为以肠道菌群为靶点的代谢性疾病的诊断防治研究提供借鉴.

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