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Role of liquid-liquid phase separation in cell physiology and diseases

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
18
DOI:
10.11569/wcjd.v28.i18.884
Key Word:
无膜区室;“液-液”相分离;疾病

Abstract´╝Ü 真核生物细胞中存在许多无膜液相区室.近年来研究发现,这些无膜区室是通过生物大分子如核酸、蛋白质凝聚发生“液-液”相分离(liquid-liquid phase separation,LLPS)后形成的.它参与基因表达调控和细胞信号转导等多个生理过程LLPS结构的失调与神经退行性疾病及肿瘤相关.本文就细胞中LLPS结构的形成、调控、功能及其与疾病的关系做一综述.

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