Correlation between perfusion state and angiogenesis indexes in gastric cancer
- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 9
- DOI:
- 10.11569/wcjd.v28.i9.347
- Key Word:
- 超声造影;胃癌;增强强度;达峰时间;血管内皮生长因子;血管生成素-2;微血管密度
Abstract： 背景 准确评估肿瘤组织的微循环血流灌注情况,对于临床治疗以及预后评估有着重要意义.超声造影(contrast-enhanced ultrasonography,CEUS)是一种敏感度极高的微循环血流监测手段,能客观反映肿瘤组织的微循环血流灌注状态,可为临床诊治提供可靠的血流动力学信息.目的运用CEUS评估胃癌(gastric cancer,GC)血流灌注状态,并探讨其与血管新生指标的相关性.方法选取在浙江医院行手术切除的66例GC患者作为研究对象(GC组).所有患者术前三天内行CEUS检查,运用时间-强度曲线测定GC组织、癌旁正常组织的增强强度、达峰时间,并采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管生成素-2(Angiopoietin-2,Ang-2)水平,术后测定组织标本微血管密度(microvessel density,MVD).同期选取72例健康志愿者作为对照组进行比较分析.结果GC组织的增强强度明显高于癌旁正常组织,差异有统计学意义(P＜0.05);GC组织的达峰时间明显短于癌旁正常组织,差异有统计学意义(P＜0.05);GC组织的MVD明显高于癌旁正常组织,差异有统计学意义(P＜0.05);GC组的VEGF、Ang-2明显高于对照组,差异有统计学意义(P＜0.05);GC组织的增强强度分别与VEGF、Ang-2、MVD呈正相关(r=0.85,r=0.81,r=0.88,P＜0.05);GC组织的达峰时间分别与VEGF、Ang-2、MVD呈负相关(r=-0.72,r=-0.73,r=-0.86,P＜0.05).结论CEUS能动态评估GC血流灌注状态,其血流参数与VEGF、Ang-2、MVD相关性良好,能为临床评估GC血管新生状态提供无创性影像学手段.
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