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Clinical significance of expression of MEG8 and TGM2 genes in gastric cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 4

DOI:: 10.11569/wcjd.v28.i4.122

Key Word:: 胃癌;母源性表达基因8;转谷氨酰胺酶2;临床意义

Abstract：背景胃癌(gastric cancer,GC)是常见恶性肿瘤之一,发病率、死亡率均排在全国、乃至全世界前列,是影响人类健康的重要问题.目前仍缺乏GC早期诊断、治疗及GC预后相关的基因靶点.目的探讨母源性表达基因8(maternally expressed gene 8,MEG8)及转谷氨酰胺酶2(transglutaminase 2,TGM2)在GC组织中的表达及临床意义.方法通过荧光定量聚合酶链式反应检测30对GC及癌旁组织中MEG8、TGM2表达情况,分析表达情况与GC患者临床病理特征相关性,通过摘录Oncomine数据库中相关研究数据,分析TGM2表达差异性及与GC患者的生存状态的相关性.结果MEG8在GC组织中的表达量低于癌旁组织(0.462±0.082 vs l.048±0.149),TGM2在GC组织中的表达量高于癌旁组织(1.202±0.143 vs 0.742±0.083),差异具有统计学意义(P＜0.05);MEG8表达与年龄、临床分期有关(P＜0.05),TGM2表达与临床分期有关(P＜O.05);TGM2表达高低与GC患者生存状态无关(P＞0.05).结论MEG8、TGM2参与GC的发生发展过程,可作为GC诊断及预后的潜在靶点.

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