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Abnormal regulation of non-coding RNAs plays a role in development and progression of hepatocellular carcinoma

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 18

DOI:: 10.11569/wcjd.v27.i18.1107

Key Word:: 肝细胞癌;microRNA;长链非编码RNA

Abstract：肝细胞癌(hepatocellular carcinoma,HCC)是一种预后较差、侵袭性较强的肿瘤.非编码RNA(non-coding RNAs,ncRNAs)是从基因组中转录出来但不被翻译成蛋白质的RNA.近年来,因其具有调节多种靶点、调节细胞增殖、分化、凋亡和发育的能力,ncRNAs成为肿瘤发生发展的关键因素.在本文中,我们讨论了ncRNAs(microRNA、长链非编码RNA和环状RNA)及在HCC发生和发展中的病理意义,探讨ncRNA对HCC的诊断和治疗潜力.

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