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Role of miR-155 in pathogenesis of inflammatory bowel disease

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 17

DOI:: 10.11569/wcjd.v27.i17.1070

Key Word:: 炎症性肠病;溃疡性结肠炎;克罗恩病;miR-155;Jarid2

Abstract：炎症性肠病(inflammatory bowel disease,IBD)是一种原因未明的肠道非特异性炎症性疾病,其发病率逐年升高,对IBD的发病机制研究有待进一步深入,找到合适的治疗方法亟待解决.近期研究表明miR-155在IBD中的作用不可小觑,可通过Jarid2/notch1信号通路及促进2型巨噬细胞分化来调节TH17分化,并通过抑制细胞毒T淋巴细胞相关抗原4调节Treg、通过细胞信号传导的抑制因子1调节肠成纤维细胞和肌成纤维细胞以及通过调节DNA双链断裂沉积来影响肠道炎症,本文就miR-155在IBD中的免疫作用机制作一综述.

Reference

[1]Weber MJ.New human and mouse microRNA genes found by homology search[J].2005,272(1).
[2]T Y, Ma.Intestinal epithelial barrier dysfunction in Crohn's disease.[J].1997,214(4).
[3]Jintao, Li,Ji, Zhang,Hongxia, Guo,etc.Critical Role of Alternative M2 Skewing in miR-155 Deletion-Mediated Protection of Colitis.[J].2018,9(Spec ).
[4]Soularue, Emilie,Lepage, Patricia,Colombel, Jean Frederic,etc.Enterocolitis due to immune checkpoint inhibitors: a systematic review[J].2018,67(11).
[5]Yasaman-Sadat,Borghei,Morteza,Hosseini.A New Eye Dual-readout Method for MiRNA Detection based on Dissolution of Gold nanoparticles via LSPR by CdTe QDs Photoinduction.[J].2019,9(1).
[6].Neutrophils as Components of Mucosal Homeostasis[J].2017,4(3).
[7]D. Bani A. Bencini.Developing ROS Scavenging Agents for Pharmacological Purposes: Recent Advances In Design of Manganese-Based Complexes with Anti-Inflammatory and Anti-Nociceptive Activity[J].2012,19(26).
[8]Qin WZ,Leng RX,Pan HF,etc.Role of microRNA-155 in autoimmunity.[J].2011,22(3).
[9]Guanglin, Cui,Aping, Yuan.A Systematic Review of Epidemiology and Risk Factors Associated With Chinese Inflammatory Bowel Disease.[J].2018,5(Spec).
[10]Hunter MM,Wang A,Parhar KS,etc.In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice.[J].2010,138(4).
[11]Shelley B. Weisser,Lisa K. Kozicky,Hayley K. Brugger,etc.Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation[J].2014,44(11).
[12]Daniel,Lu,Tracy,Yamawaki,Hong,Zhou,etc.Limited differential expression of miRNAs and other small RNAs in LPS-stimulated human monocytes.[J].2019,14(3).
[13]K Inagaki-Ohara,A Sasaki,G Matsuzaki,etc.Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice[J].2006,55(2).
[14]Brazil,J.C.,Louis,N.A.,Parkos,C.A..The role of polymorphonuclear leukocyte trafficking in the perpetuation of inflammation during inflammatory bowel disease[J].2013,19(7).
[15]Yujin Liu,Yalan Dong,Xiwen Zhu,etc.MiR-155 inhibition ameliorates 2, 4, 6-Trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis in rat via influencing the differentiation of Th17 cells by Jarid2[J].2018,64.
[16]Wood, C. David,Carvell, Thomas,Gunnell, Andrea,etc.Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells[J].2018,92(19).
[17]Surajit, Pathak,Alessia Rosaria, Grillo,Melania, Scarpa,etc.MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis.[J].2015,47.
[18]B M J, Owens,A, Simmons.Intestinal stromal cells in mucosal immunity and homeostasis.[J].2013,6(2).
[19]Zhang, Yingying,Sun, Entao,Li, Xueqin,etc.miR-155 contributes to Df1-induced asthma by increasing the proliferative response of Th cells via CTLA-4 downregulation[J].2017,314.
[20]Yamaguchi T,Sakaguchi S,Wing K.Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation.[J].2011,32(9).
[21]Kevin J. Maloy,Fiona Powrie.Intestinal homeostasis and its breakdown in inflammatory bowel disease[J].2011,474(Jun.16 TN.7351).
[22]Perret,R.,Hebeisen,M.,Escobar,T.M.,etc.MicroRNA-155 is required for effector cd8+ t cell responses to virus infection and cancer[J].2013,38(4).
[23]Gao,Chao,Xiaoli,Li,Yahong,Ji,etc.MiR-155 controls follicular Treg cell-mediated humoral autoimmune intestinal injury by inhibiting CTLA-4 expression.[J].2019,71.