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Factors involved in balance of Th17/Treg cells: Clinical implications in inflammatory bowel disease

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
5
DOI:
10.11569/wcjd.v27.i5.336
Key Word:
辅助性;T细胞17;调节性T细胞;平衡;炎症性肠病

Abstract´╝Ü 在炎症性肠病(inflammatory bowel disease,IBD)中,自身免疫由辅助性T细胞17(T helper cell 17,Th17)细胞驱动并被调节性T细胞(regulatory cells,Tregs)抑制,因此重塑Th 17/Treg细胞的平衡对于治疗IBD至关重要.有许多因素参与影响了Th 17/Treg平衡,其中包括TCR信号,共刺激信号,细胞因子信号,代谢水平,微生物群等.下面,本文将讲述它们在调节Th 17/Treg平衡中的作用以及对IBD的影响.

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