Paper - WANFANG MED ONLINE

You Position: Home > Paper

Enterochromaffin cells and gastrointestinal diseases

( views:105, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 2

DOI:: 10.11569/wcjd.v27.i2.117

Key Word:: 肠嗜铬细胞;5-HT;生理功能;免疫调节;肠道疾病

Abstract：肠嗜铬细胞(Enterochromaffin cell,EC)由肠上皮基底干细胞分化而来,由于其特殊的组织化学染色特性而得名.EC主要分泌5-羟色胺,并产生机体95％的5-羟色胺(5-hydroxytryptamine,5-HT).EC作为化学感受器通过肠-脑回路与神经细胞建立直接突触联系,感受胃肠道摄入的食物以及相关化学因子,并以此调控胃肠道吸收营养物质.另外,EC还参与肠道免疫调节功能.值得注意的是EC数量以及其分泌的5-HT浓度的变化与多种肠道疾病密切相关.总之,EC对胃肠道健康的作用不容小觑.

Reference

[1]S W, Carmichael.The adrenal chromaffin vesicle: an historical perspective.[J].1983,7(1).
[2]O. A. Lyubashina,I.I. Busygina,S. S. Panteleev,etc.The 5HT4 Receptor Agonist Prucalopride Suppresses Abdominal Nociception[J].2015,461.
[3]Roth K. A.,Gordon J. I..Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice.[J].1990.
[4]G, Csaba,E, Kapa,M, Cserhalmi.Hormone receptor studies on frog macrophage cells by means of histamine, serotonin and indoleacetic acid.[J].1975,65(2).
[5]Jennifer RO&#8217,Hara,Alan ELomax,etc.Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon[J].2007,56(2).
[6].Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis[J].2015,161(2).
[7]Martins, Patricia,Fakhry, Josiane,de Oliveira, Enio Chaves,etc.Analysis of enteroendocrine cell populations in the human colon[J].2017,367(2).
[8]Y.Cetin.Secretin-cells of the mammalian intestine contain serotonin[J].1990,93(6).
[9]Xi, Rongwen,Wang, Chenhui.Keeping intestinal stem cell differentiation on the Tramtrack[J].2015,9(3).
[10]Martin, Alyce M.,Lumsden, Amanda L.,Young, Richard L.,etc.Regional differences in nutrient-induced secretion of gut serotonin.[J].2017,5(6).
[11]Okaty, Benjamin W.,Freret, Morgan E.,Rood, Benjamin D.,etc.Multi-Scale Molecular Deconstruction of the Serotonin Neuron System[J].2015,88(4).
[12]Jenny M,Duluc I,Uhl C,etc.Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium.[J].2002,21(23).
[13]Janice J, Kim,Huaqing, Wang,Joshua D, Terc,etc.Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.[J].2015,309.
[14]Monika, Kloza,Marta, Baranowska-Kuczko,Anna, P?dzińska-Betiuk,etc.[Serotonin hypothesis and pulmonary artery hypertension].[J].2014,68.
[15]Latorre, R.,R Latorre,Sternini, C.,etc.Enteroendocrine cells: a review of their role in brain-gut communication[J].2016,28(5).
[16]C, Ito,Y, Isobe,K, Tsuchida,etc.5-Hydroxytryptamine3 receptor and regulation of gastric emptying in rats.[J].1900,331(2).
[17]Bohorquez, Diego V.,Shahid, Rafiq A.,Erdmann, Alan,etc.Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells[J].2015,125(2).
[18]Martin, Alyce M.,Young, Richard L.,Leong, Lex,etc.The Diverse Metabolic Roles of Peripheral Serotonin[J].2017,158(5).
[19]Ph.Heitz,JuliaM.Polak,MarlisKasper,etc.Immunoelectron cytochemical localization of motilin and substance P in rabbit bile duct enterochromaffin (EC) cells[J].1977,50(4).
[20]Patey N,Brooks EM,Mawe GM,etc.Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients.[J].2010,139(1).
[21]Worrall D M,Williams D C.Sodium ion-dependent transporters for neurotransmitters: a review of recent developments[J].1994.
[22]Bellono, Nicholas W.,Bayrer, James R.,Leitch, Duncan B.,etc.Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways[J].2017,170(1).
[23]DiSabatino,A.,Giuffrida,P.,Vanoli,A.,etc.Increase in neuroendocrine cells in the duodenal mucosa of patients with refractory celiac disease[J].2014,109(2).
[24]Neshat,Barajas Espinosa A,Bertrand PP.Analysis of real-time serotonin (5-HT) availability during experimental colitis in mouse.[J].2010,298(3 Pt.1).
[25]Bausch, Birke,Tischler, Arthur S.,Schmid, Kurt W.,etc.Max Schottelius: Pioneer in Pheochromocytoma[J].2017,1(7).
[26]Collingridge GL,Isaac JT,Wang YT.Receptor trafficking and synaptic plasticity.[J].2004,5(12).
[27]Grasberger,H.,Chang,L.,Presson,A.P.,etc.Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes[J].2013,108(11).
[28]Shinichi, Kato.Role of serotonin 5-HT? receptors in intestinal inflammation.[J].2013,36.
[29]V, ERSPAMER,B, ASERO.Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine.[J].1952,169(4306).
[30].Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets[J].2013,10(8).
[31]M, Thompson,K A, Fleming,D J, Evans,etc.Gastric endocrine cells share a clonal origin with other gut cell lineages.[J].1990,110(2).
[32]Dan-Yan, Li,Yun-Kai, Dai,Yun-Zhan, Zhang,etc.Systematic review and meta-analysis of traditional Chinese medicine in the treatment of constipation-predominant irritable bowel syndrome.[J].2017,12(12).
[33]Michael J, Shimko,Eric J, Zaccone,Janet A, Thompson,etc.Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells.[J].2014,2(7).
[34]Yoo, Bryan B.,Mazmanian, Sarkis K..The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut[J].2017,46(6).
[35]Margaret (Mandy) R. MacLean.The serotonin hypothesis in pulmonary hypertension revisited: targets for novel therapies (2017 Grover Conference Series):[J].2018,8(2).
[36]Jernej B,Rinner I,Schauenstein K,etc.mRNA expression of serotonin receptors in cells of the immune tissues of the rat.[J].2000,14(3).
[37]Dou, Kun,Xi, Rongwen,Chen, Hongyan,etc.Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages[J].2015,142(19).
[38]Daws LC,Gould GG.Ontogeny and regulation of the serotonin transporter: providing insights into human disorders.[J].2011,131(1).
[39]Peta J, O'Connell,Xiangbin, Wang,Matilde, Leon-Ponte,etc.A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.[J].2006,107.
[40]Koh, Ara,De Vadder, Filipe,Kovatcheva-Datchary, Petia,etc.From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites[J].2016,165(6).