Paper - WANFANG MED ONLINE

You Position: Home > Paper

Intestinal microbiome and autoimmune liver disease

( views:29, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 1

DOI:: 10.11569/wcjd.v27.i1.50

Key Word:: 自身免疫性肝炎;原发性硬化性胆管炎;原发性胆汁性胆管炎;先天免疫;肠菌生态失衡;黏膜屏障;益生菌

Abstract：目前,已被证实与肠道微生物有关的疾病涉及人体的多个器官系统疾病的发生与发展.肠道微生物群是微生物抗原和活化免疫细胞的蓄积体,肠道菌群组成的改变(生物障碍)可以破坏肠道和共生菌的系统免疫耐受性.肠内的Toll样受体可以识别微生物相关的分子模式和T辅助淋巴细胞的形状亚群,这些亚群可以与宿主抗原(分子模拟)交叉反应.活化的肠源性淋巴细胞可以迁移到淋巴结,肠源性微生物抗原可以转移到肠外部位.炎症小体可以在肝细胞和肝星状细胞中形成,它们可以驱动促炎、免疫介导和纤维化反应.本文就肠道微生物在自身免疫性肝病发病机制和治疗上的作用的研究作一综述和评价.

Reference

[1]Rahul Shubhra Mandal,Sudipto Saha,Santasabuj Das.Metagenomic Surveys of Gut Microbiota[J].2015,(3).
[2]Yiyangzi Ma,A Shi,engtao Li,etc.Applications of Next-generation Sequencing in Systemic Autoimmune Diseases[J].2015,(4).
[3]程昉,徐沪济.转录因子FOXP3的研究进展[J].2008,(1).
[4]Czaja, Albert J..Targeting Apoptosis in Autoimmune Hepatitis[J].2014,59(12).
[5]Eaton,J.E.,Talwalkar,J.A.,Lazaridis,K.N.,etc.Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management[J].2013,145(3).
[6]Tze Guan Tan,Esen Sefik,Naama Geva-Zatorsky,etc.Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice[J].2016,113(50).
[7]Amy Koh,Charles Maliszewski,Thomas Van Dyke,etc.A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells[J].2004,172(8).
[8]Czaja, Albert J..Transitioning from Idiopathic to Explainable Autoimmune Hepatitis[J].2015,60(10).
[9]Bo, Li,Carlo, Selmi,Ruqi, Tang,etc.The microbiome and autoimmunity: a paradigm from the gut-liver axis.[J].2018,(Spec ).
[10]Rui, Lin,Lu, Zhou,Jie, Zhang,etc.Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis.[J].2015,8(5).
[11]Andrew J. Macpherson,Markus B. Geuking,Kathy D. McCoy.Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria[J].2005,115(2).
[12]Lv, Long-Xian,Fang, Dai-Qiong,Shi, Ding,etc.Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis[J].2016,18(7).
[13]David A. Brenner,Ekihiro Seki,Gyongyi Szabo,etc.Innate immunity in alcoholic liver disease[J].2011,300(4Part 1).
[14]Nie,J.,Li,X.,Wang,C.,etc.Toll-like receptor 4 increases intestinal permeability through up-regulation of membrane PKC activity in alcoholic steatohepatitis[J].2013,47(6).
[15]Luo, Xin M.,Liao, Xiaofeng,Zhang, Husen,etc.Dynamics of Gut Microbiota in Autoimmune Lupus[J].2014,80(24).
[16]Johansson, MEV,Phillipson, M,Petersson, J,etc.The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria[J].2008,105(39).
[17]Borja, Sánchez,Arancha, Hevia,Sonia, González,etc.Interaction of Intestinal Microorganisms with the Human Host in the Framework of Autoimmune Diseases.[J].2015,6.
[18]Giuseppina, Frasca,Venera, Cardile,Carmelo, Puglia,etc.Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells.[J].2012,5.
[19]Tenailleau E,Cherbut C,Martin L,etc.Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident[J].2005,99(1).
[20]赵凡,李春保.肠道菌Akkermansia muciniphila的特性及其与机体健康的关系[J].2017,(6).
[21]Grant AJ,Curbishley SM,Miles A,etc.Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis.[J].2004,200(11).
[22]F Barreau,JP Hugot.Intestinal barrier dysfunction triggered by invasive bacteria[J].2014,17.
[23]Hester J,Li X,Kalady M,etc.A novel method for determining microflora composition using dynamic phylogenetic analysis of 16S ribosomal RNA deep sequencing data.[J].2011,98(4).
[24]Ruehlemann, Malte Christoph,Heinsen, Femke-Anouska,Zenouzi, Roman,etc.Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis[J].2017,66(4).
[25]Manns MP,Czaja AJ,Gorham JD,etc.Diagnosis and management of autoimmune hepatitis.[J].2010,51(6).
[26]Karin M,Matsuzawa A,Mino T,etc.Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.[J].2010,11(1).
[27]Rupp,C.,Friedrich,K.,Folseraas,T.,etc.Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis[J].2014,39(8).
[28]Annika Wahlstrom,Sama I. Sayin,Hanns-Ulrich Marschall,etc.Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism[J].2016,24(1).
[29]Ian N. Hines,Michael Kremer,Gakuhei Son.Contribution of Gut Bacteria to Liver Pathobiology[J].2010,2010(Toll).
[30]Van Praet, Jens T.,Donovan, Erin,Vanassche, Inge,etc.Commensal microbiota influence systemic autoimmune responses[J].2015,34(4).
[31]Li, You,Tang, Ruqi,Leung, Patrick S. C.,etc.Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases[J].2017,16(9).
[32]Lutgendorff F,Phan V,Soderholm JD,etc.Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate.[J].2010,16(7).
[33]Mukherjee, Sohini,Hooper, Lora V..Antimicrobial Defense of the Intestine[J].2015,42(1).
[34]Round, J.L.,Mazmanian, S.K..Inducible Foxp3~+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota[J].2010,107(27).
[35]Kate Schroder,Jurg Tschopp.The Inflammasomes[J].2010,140(6).
[36]E, Seki,H, Tsutsui,H, Nakano,etc.Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta.[J].2001,166.
[37]Zenewicz L,Kinnebrew MA,Ubeda C.Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.[J].2010,201(4).
[38]De Minicis S,Seki E,Gwak GY.CCR1 and CCR5 promote hepatic fibrosis in mice.[J].2009,119(7).
[39]Fredrik, B?ckhed,Ruth E, Ley,Justin L, Sonnenburg,etc.Host-bacterial mutualism in the human intestine.[J].2005,307(5717).
[40]Ruqi, Tang,Yiran, Wei,Yanmei, Li,etc.Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy.[J].2017,(Spec ).
[41]Fei, Li,Changtao, Jiang,Kristopher W, Krausz,etc.Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.[J].2013,4.
[42]Melum E,Franke A,Schramm C,etc.Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.[J].2011,43(1).
[43]T P, Bonnert,K E, Garka,P, Parnet,etc.The cloning and characterization of human MyD88: a member of an IL-1 receptor related family.[J].1997,402(1).
[44]Julio Madrigal-Matute,Ana Maria Cuervo.Regulation of Liver Metabolism by Autophagy[J].2016,(2).
[45]Michael Bordonaro,Darina L. Lazarova,Leonard H. Augenlicht,etc.Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate[J].2002,97(1).
[46]Tang Y,Chen Y,Jiang H,etc.Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death.[J].2011,18(4).
[47]Reiner Wiest,Guadalupe Garcia-Tsao.Bacterial translocation (BT) in cirrhosis[J].2005,41(3).
[48]Koji Atarashi,Takeshi Tanoue,Tatsuichiro Shima,etc.Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species[J].2011,331(Jan.21 TN.6015).
[49]Konturek, P. C.,Haziri, D.,Brzozowski, T.,etc.Emerging Role of Fecal Microbiota Therapy in the Treatment of Gastrointestinal and Extra-Gastrointestinal Diseases[J].2015,66(4).
[50]Reiner Wiest,Agustin Albillos,Michael Trauner,etc.Targeting the gut-liver axis in liver disease[J].2017,67(5).
[51]Kuhn, Kristine A.,Pedraza, Isabel,Demoruelle, M. Kristen.Mucosal Immune Responses to Microbiota in the Development of Autoimmune Disease[J].2014,40(4).
[52]Islam KB,Fukiya S,Hagio M,etc.Bile acid is a host factor that regulates the composition of the cecal microbiota in rats.[J].2011,141(5).
[53]Golenbock DT,Christ WJ,Chow JC,etc.Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.[J].1999,274(16).
[54]Sabino, Joao,Vieira-Silva, Sara,Machiels, Kathleen,etc.Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD[J].2016,65(10).
[55]Koji Atarashi,Takeshi Tanoue,Kenshiro Oshima,etc.T_(reg) induction by a rationally selected mixture of Clostridia strains from the human microbiota[J].2013,500(Aug.8 TN.7461).
[56]Miyake,Y.,Yamamoto,K..Role of gut microbiota in liver diseases[J].2013,43(2).
[57]Parseus, Ava,Sommer, Nina,Sommer, Felix,etc.Microbiota-induced obesity requires farnesoid X receptor[J].2017,66(3).
[58]Hov, Johannes R.,Kummen, Martin.Intestinal microbiota in primary sclerosing cholangitis[J].2017,33(2).
[59]Schnabl,B.,Seki,E..Role of innate immunity and the microbiota in liver fibrosis: Crosstalk between the liver and gut[J].2012,590(3).
[60]Strowig,T.,Henao-Mejia,J.,Elinav,E.,etc.Inflammasomes: Far beyond inflammation[J].2012,13(4).
[61].Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis[J].2015,13(13).
[62]James D. Lewis,Jun Chen,Sue A. Keilbaugh,etc.Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes[J].2011,334(Oct.7 TN.6052).
[63]Ganz M,Kodys K,Szabo G,etc.Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.[J].2011,54(1).
[64]Beckley K. Davis,Haitao Wen,Jenny P. Y. Ting.The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases[J].2011,29.
[65]Hov, Johannes R.,Karlsen, Tom H..The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts[J].2017,37(4).
[66]Haruta I,Kikuchi K,Hashimoto E,etc.Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation.[J].2010,90(4).
[67]Meng Z,Wu J,Jiang.Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific.[J].2010,129(3).
[68]Tan,J.,McKenzie,C.,Potamitis,M.,etc.The Role of Short-Chain Fatty Acids in Health and Disease[J].2014,121.
[69]Foss A,Schrumpf E,Brandsaeter B,etc.Liver transplantation in primary sclerosing cholangitis.[J].2006,26(1).
[70]Spadoni, Ilaria,Zagato, Elena,Bertocchi, Alice,etc.A gut-vascular barrier controls the systemic dissemination of bacteria[J].2015,350(Nov.13 TN.6262).
[71]Manns M P,Griffin K J,Sullivan K F,etc.LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.[J].1991.
[72]Jorgensen,R.A.,Keach,J.C.,Talwalkar,J.A.,etc.Randomised clinical trial: Vancomycin or metronidazole in patients with primary sclerosing cholangitis - A pilot study[J].2013,37(6).
[73]Martinon F,Mayor A,Tschopp J.The inflammasomes: guardians of the body.[J].2009,27.
[74]Trivedi,P.J.,Adams,D.H..Mucosal immunity in liver autoimmunity: A comprehensive review[J].2013,46.
[75]Cullen SN,Chapman RW.Review article: current management of primary sclerosing cholangitis.[J].2005,21(8).
[76]Osamu Takeuchi,Shizuo Akira.Pattern Recognition Receptors and Inflammation[J].2010,140(6).
[77]Xinyang Li,Jun Shen,Zhihua Ran.Crosstalk between the gut and the liver via susceptibility loci: Novel advances in inflammatory bowel disease and autoimmune liver disease[J].2017,175.
[78]Fraher,M.H.,O'Toole,P.W.,Quigley,E.M.M..Techniques used to characterize the gut microbiota: A guide for the clinician[J].2012,9(6).
[79]Prajwal, Gurung,Bofeng, Li,R K, Subbarao Malireddi,etc.Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.[J].2015,5.
[80]Jiang, Changtao,Xie, Cen,Li, Fei,etc.Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease[J].2015,125(1).
[81]Talal A. Chatila,Bana Jabri,Gloria Tran,etc.The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota[J].2011,332(TN.6032).
[82]Kabelitz D.Expression and function of Toll-like receptors in T lymphocytes.[J].2007,19(1).
[83]M P,Francino.Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances.[J].2015,6.
[84]Peter J, Turnbaugh,Vanessa K, Ridaura,Jeremiah J, Faith,etc.The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice.[J].2009,1(6).
[85]Quraishi, Mohammed Nabil,Sergeant, Martin,Kay, Gemma,etc.The gut-adherent microbiota of PSC-IBD is distinct to that of IBD[J].2017,66(2).
[86]Sorina Georgiana, Boaru,Erawan, Borkham-Kamphorst,Lidia, Tihaa,etc.Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease.[J].2012,9(1).
[87]Marc R, Bomhof,Jill A, Parnell,Hena R, Ramay,etc.Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial.[J].2018,(Spec ).
[88]L R, Lopetuso,F, Scaldaferri,G, Bruno,etc.The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors.[J].2015,19(6).
[89]Wu HJ,Ivanov II,Darce J,etc.Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.[J].2010,32(6).
[90]L, Legutko.[Blood serum iron and copper content depending on the degree of progression of acute leukemia in children].[J].1978,53(7).
[91]Michelle Epstein,James M. Wright.Severe multisystem disease caused by trimethoprim-sulfamethoxazole: Possible role of an in vitro lymphocyte assay[J].1990,86(Part 1).
[92]Fasano,A..Leaky gut and autoimmune diseases[J].2012,42(1).
[93]Medzhitov R,Pasare C.Toll-like receptors and acquired immunity.[J].2004,16(1).
[94]Yukihiro Furusawa,Yuuki Obata,Shinji Fukuda,etc.Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells[J].2013,504(Dec.26 TN.7480).
[95]Rebecca Rogier,Marije I. Koenders,Shahla Abdollahi-Roodsaz.Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis[J].2015,(1).
[96]Kiyoshi Takeda,Masahiro Yamamoto.Current Views of Toll-Like Receptor Signaling Pathways[J].2010,2010(Toll).
[97]Nicholas Arpaia,Clarissa Campbell,Xiying Fan,etc.Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation[J].2013,504(Dec.26 TN.7480).
[98]Torres, J.,Bao, X.,Goel, A.,etc.The features of mucosa-associated microbiota in primary sclerosing cholangitis[J].2016,43(7).
[99]Gueimonde, M.,Suárez, A.,Ruas-Madiedo, P.,etc.Interaction of Bifidobacterium bifidum LMG13195 with HT29 Cells Influences regulatory-T-cell-associated chemokine receptor expression[J].2012,78(8).