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Progress in research of sphingolipids in hepatocellular carcinoma

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 36

DOI:: 10.11569/wcjd.v26.i36.2109

Key Word:: 鞘脂;肝细胞癌;神经酰胺;糖鞘脂;1磷酸鞘氨醇

Abstract：鞘脂是一系列新型的脂质生物调控分子,在调控细胞生长、分化、增殖以及凋亡等方面具有重要的生物学作用.鞘脂代谢紊乱可以诱发包括肝细胞癌(hepatocellular carcinoma,HCC)在内的多种疾病的发生.随着脂质组学技术的发展,越来越多的研究表明鞘脂在HCC发生、发展及转归中起到重要的作用.研究表明鞘脂可以作为诊断HCC的新型标志物,且调控鞘脂代谢通路可能成为治疗HCC的潜在靶点.本文从鞘脂的分类、代谢通路,鞘脂对肝细胞增殖与凋亡的影响,鞘脂在HCC的发生发展中的作用,以及鞘脂作为HCC诊断、治疗靶点的可能性等方面的研究现状做一综述.

Reference

[1]蒋莹莹,铁偲,王扬,等.血清鞘脂用于乙肝相关甲胎蛋白阴性肝细胞癌的诊断价值研究[J].2018,(5).
[2]Qu, Feng,Zheng, Su-Jun,Liu, Shuang,etc.Serum Sphingolipids Reflect the Severity of Chronic HBV Infection and Predict the Mortality of HBV-Acute-on-Chronic Liver Failure.[J].2014,9(8).
[3]Chen, Bryan Wei,Chen, Wei,Liang, Hui,etc.Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells[J].2015,14(8).
[4]Mari M,Fernandez-Checa JC.Sphingolipid signalling and liver diseases.[J].2007,27(4).
[5]Wang,Z.,Liu,H.,Li,Y.,etc.Aberrant fucosylation of glycosphingolipids in human hepatocellular carcinoma tissues[J].2014,34(1).
[6]Jain, Amrita,Beutel, Oliver,Ebell, Katharina,etc.Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis[J].2017,130(2).
[7]Zhao,Y.,Chen,T.,Li,J.,etc.Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma[J].2012,32(2).
[8]Jeremy C. Allegood,Christopher A. Haynes,M. Cameron Sullards,etc.Sphingolipidomics: Methods for the comprehensive analysis of sphingolipids[J].2009,877(26).
[9]Junfei, Jin,Weijia, Liao,Wenmin, Yao,etc.Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate.[J].2016.
[10]M, Ali,J, Fritsch,H, Zigdon,etc.Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization.[J].2013,4.
[11]杜昊骐,于汉杰,贾丽苑,等.糖鞘脂分析技术及相关疾病研究进展[J].2016,(1).
[12]David J, Montefusco,Jeremy C, Allegood,Sarah, Spiegel,etc.Non-alcoholic fatty liver disease: Insights from sphingolipidomics.[J].2018,(Spec ).
[13][Noauthornameavailable].EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma[J].2012,56(4).
[14]Yin, Yancun,Xu, Maolei,Gao, Ju,etc.Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling[J].2018,214(9).
[15]Tagaram HR,Divittore NA,Barth BM,etc.Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma.[J].2011,60(5).
[16]Ji, Qian,Zheng, Guo-Yin,Xia, Wei,etc.Inhibition of invasion and metastasis of human liver cancer HCCLM3 cells by portulacerebroside A[J].2015,53(1/6).
[17]Chen-Shiou Wu,Chia-Jui Yen,Ruey-Hwang Chou,etc.Cancer-Associated Carbohydrate Antigens as Potential Biomarkers for Hepatocellular Carcinoma.[J].2012,7(7).
[18]Qu, Liang,Qu, Feng,Jia, Zhixin,etc.Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide[J].2015,170.
[19]Podbielska, Maria,Szulc, Zdzislaw M.,Kurowska, Ewa,etc.Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line[J].2016,57(11).
[20]Raghavendra, Pralhada Rao,Nanditha, Vaidyanathan,Mathiyazhagan, Rengasamy,etc.Sphingolipid metabolic pathway: an overview of major roles played in human diseases.[J].2013,2013.
[21]Thomas, Kolter,Konrad, Sandhoff.Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.[J].2005,21.
[22]Teodor, Kapitanov,Ulf P, Neumann,Maximilian, Schmeding.Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization-A Meta-Analysis.[J].2015,2015.
[23]Cheng, Jung-Chien,Wang, Evan Y.,Yi, Yuyin,etc.S1P Stimulates Proliferation byUpregulating CTGF Expression through S1PR2-Mediated YAP Activation[J].2018,16(10).
[24]Pei-Hua, Lu,Min-Bin, Chen,Yuan-Yuan, Liu,etc.Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.[J].2017,8(14).
[25]Krautbauer, Sabrina,Wiest, Reiner,Liebisch, Gerhard,etc.Associations of systemic sphingolipids with measures of hepatic function in liver cirrhosis are related to cholesterol[J].2017,131.
[26]Pinho,S.S.,Carvalho,S.,Marcos-Pinto,R.,etc.Gastric cancer: Adding glycosylation to the equation[J].2013,19(11).
[27]Colell,A.,Fernández-Checa,J.C.,García-Ruiz,C.,etc.Hepatocarcinogenesis and ceramide/cholesterol metabolism[J].2012,12(4).
[28].COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells.[J].2018,20(4).