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Liraglutide combined with vitamin E alleviates liver injury and insulin resistance in mice with nonalcoholic fatty liver disease
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- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 29
- DOI:
- 10.11569/wcjd.v26.i29.1688
- Key Word:
- 利拉鲁肽;维生素E;非酒精性脂肪性肝病;胰岛素抵抗
Abstract： 目的 探讨利拉鲁肽联合维生素E对非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)小鼠肝损伤和胰岛素抵抗的改善作用和潜在的机制.方法 C57BL/6小鼠分为对照组,NAFLD小鼠模型组,利拉鲁肽治疗组、利拉鲁肽联合维生素E治疗组.收集各组小鼠血液和肝组织并进行生化和病理检测;并应用Western blotting检测各组小鼠肝组织IRS-1磷酸化水平.结果 利拉鲁肽抑制高脂饮食诱导的小鼠体重增加、肥胖、肝细胞肿胀、肝脂质蓄积和胶原纤维沉积、血浆游离脂肪酸、甘油三酯、胆固醇、血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、葡萄糖和胰岛素水平以及胰岛素抵抗稳态模型值.Western blotting结果表明,利拉鲁肽通过激活IRS-1信号通路增加NAFLD小鼠对胰岛素的敏感性.此外,维生素E与利拉鲁肽在抗NAFLD具有协同作用.结论 本研究揭示利拉鲁肽联合维生素E是治疗NAFLD有吸引力的治疗策略.
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