Paper - WANFANG MED ONLINE

You Position: Home > Paper

Laparoscopic cholecystectomy combined with Xiaoyanlidan tablets for treatment of acute cholecystitis patients: Curative effect and impact on prognosis and serological indicators

( views:23, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 25

DOI:: 10.11569/wcjd.v26.i25.1523

Key Word:: 腹腔镜;胆囊切除术;消炎利胆片;术后疗效;血清学指标

Abstract：目的探讨腹腔镜下胆囊切除术辅用消炎利胆片在治疗急性胆囊炎上的疗效、预后及血清学指标的变化情况.方法选取2017-01/2017-12在浙江省嘉兴市中医医院治疗的100例急性胆囊炎患者,随机分为观察组和对照组,各50例.对照组仅给予腹腔镜胆囊切除术,观察组在对照组基础上辅用消炎利胆片治疗,观察比较两组患者术后的临床疗效、并发症发生率、血清学指标[C反应蛋白(C reactive protein,CRP)、血清降钙素原(procalcitonin,PCT)、血清癌(cancer antigen,CA)19-9、促甲状腺激素(thyroid-stimulating hormone,TSH)、胰岛素(insulin,Ins)]的变化、术后胆总管结石复发率及肝功能指标.结果观察组的术后总有效率为90.00％,明显高于对照组的76.00％,差异有统计学意义(P＜0.05);观察组术后并发症的发生率为2.00％,明显低于对照组的16.00％,差异有统计学意义(P＜0.05);观察组术后1wk的血清学指标CRP、PCT、CA19-9、TSH及Ins明显低于对照组,差异有统计学意义(P＜0.05);观察组术后胆总管结石的发生率为10.00％明显低于对照组的26.00％,差异有统计学意义(P＜0.05);观察组患者术后的谷丙转氨酶、谷草转氨酶降低程度比对照组的明显,差异有统计学意义(P＜0.05).结论腹腔镜胆囊切除术辅用消炎利胆片在治疗急性胆囊炎上,能有效改善患者机体的炎症反应,降低术后并发症发生率,提高治愈的总有效率,值得临床推广.

Reference

[1]李世忠.急诊手术联合生长抑素治疗急性胆囊炎对患者炎症状态、肝功能水平的影响[J].2016,(15).
[2]金辉,连加玉,智会,等.头孢西丁联合消炎利胆片与手术治疗老年胆结石效果对比[J].2017,(5).
[3]张小梅.RP-HPLC法同时测定消炎利胆片中咖啡酸、异夏佛塔苷、夏佛塔苷的含量[J].2016,(18).
[4]何小东,刘乔飞.肝胆管结石病的诊断与治疗[J].2015,(4).
[5]王存生,刘长春,周树理,等.腹腔镜胆囊切除术治疗急性胆囊炎420例[J].2014,(4).
[6]伍隽华,邝乃乐.经皮经肝胆囊穿刺引流联合腹腔镜胆囊切除术治疗急性胆囊炎合并糖尿病[J].2017,(2).
[7]陆深泉,冯春善,黄英武,等.急性胆囊炎腹腔镜胆囊切除术与开腹手术的对比研究[J].2014,(6).
[8]李震寰,黄晓方,鲁琪,等.手术联合消炎利胆片治疗老年胆结石患者临床效果研究[J].2016,(6).
[9]张华林.消炎利胆片治疗中医肝胆湿热型慢性胆囊炎的临床研究[J].2016,(11).
[10]张宇,宋月坤.腹腔镜胆囊切除术在急性胆囊炎患者中的应用[J].2015,(13).
[11]Antonio Navarro-Sánchez,Hutan Ashraifan,Aggelos Laliotis,etc.Single-stage laparoscopic management of acute gallstone pancreatitis: outcomes at different timings[J].2016,(3).
[12]盛涛,李敬东,赵国刚.腹腔镜胆囊切除术治疗急性胆囊炎的手术时机选择及疗效分析[J].2014,(12).
[13]刘洋,程南生,叶辉,等.口服消炎利胆片对肝内胆管结石术后患者胆汁成分的影响[J].2014,(10).
[14]雷凌,张栗,崔海涛,等.腹腔镜胆总管探查联合消炎利胆片治疗胆囊切除术后复发胆总管结石患者相关血清学指标变化[J].2016,29(0).
[15]李蔚,邬善敏,陈辰,等.早期与延期腹腔镜胆囊切除术治疗急性胆囊炎疗效及安全性的Meta分析[J].2015,(3).
[16].Risk Factors for Difficult Laparoscopic Cholecystectomy in Acute Cholecystitis[J].2016.
[17]雷凌,张玉洁,吴炜,等.腹腔镜胆总管探查联合消炎利胆片治疗胆囊切除术后复发胆总管结石的临床价值[J].2017,35(0).
[18]刘新.腹腔镜微创手术与消炎利胆片联用治疗急性胆囊炎的疗效评价[J].2014,(5).
[19]Degraeve,C.,Sabbagh,C.,Cosse,C.,etc.Can we consider day-case laparoscopic cholecystectomy for acute calculous cholecystitis? Identification of potentially eligible patients[J].2014,186(1).
[20].Feasibility of single-incision laparoscopic cholecystectomyfor acute cholecystitis[J].2015,0(19).
[21]Walsh, U.,Sen, M.,Watfah, J.,etc.Impact of a dedicated emergency surgical unit on early laparoscopic cholecystectomy for acute cholecystitis[J].2016,98(2).