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Role of gut-liver axis dysfunction in pathogenesis of non-alcoholic fatty liver disease: Implications for treatment strategies

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
24
DOI:
10.11569/wcjd.v26.i24.1439
Key Word:
肠-肝轴;非酒精性脂肪肝病;肠道屏障;肠道微生物

Abstract´╝Ü 众所周知,非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)作为一个慢性代谢性疾病,其发病机制复杂,涉及到诸多因素.其中肠道微生物失衡所导致的机体代谢紊乱是NAFLD发生发展的一个重要诱因.相关研究发现肠道菌群的失调可引起肠道屏障的破坏,进而导致相关有毒代谢产物入血和细菌移位的发生,诱发肝脏炎症反应和损伤.在此过程中,肠肝之间的“对话”体现了肠-肝轴在NAFLD/NASH发病过程中的重要地位.因此,本文将就肠-肝轴参与NAFLD的发病机制及相关潜在的治疗策略进行一个简要的评述.

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