Abstract： AIM To assess the value of magnetic resonance imaging (MRI) dynamic enhancement combined with diffusion weighted imaging in the diagnosis of advanced gastric cancer (GC).METHODS A total of 102 patients suspected of having advanced GC from February 2016 to October 2017 of Tianjin Ninghe District Hospital. All patients underwent pathological examination after surgery. Before surgery, the patients underwent MRI dynamic enhancement scanning and diffusion weighted imaging. Preoperative diagnostic results were compared with postsurgical pathologic results, and the diagnostic efficacy of MRI dynamic enhancement plus diffusion weighted imaging in patients with advanced GC was then analyzed using the receiver operating characteristic curve. RESULTS Of the 102 patients included, 89 (87.25％) were diagnosed with advanced GC and 13 (12.75％) had benign gastric disease. Ktrans, Vc, and Kep were significantly higher in advanced GC than in benign diseases (P＜ 0.05). The diffuse weighted signal b = 400, b = 800, and ADC value were significantly lower in advanced GC than in benign gastric disease (P＜ 0.05). There was no statistically significant difference in the sensitivity and specificity between MRI dynamic enhancement and diffuse weighted imaging (P＜ 0.05). The sensitivity and specificity of MRI dynamic enhancement combined with diffusion weighted imaging for the diagnosis of GC were significantly higher than those of either of them alone (P＜ 0.05). CONCLUSION MRI dynamic enhancement combined with diffusion weighted imaging has satisfactory sensitivity and specificity in the diagnosis of advanced GC.